Plasma substance P level in patients with schizophrenia: A cross-sectional study

Takuto Ishida, Hiroyuki Uchida, Takefumi Suzuki, Shinichiro Nakajima, Koichiro Watanabe, Haruo Kashima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aspiration pneumonia is a serious health concern in older patients with schizophrenia. In this study, we examined clinical and demographic variables that could impact the plasma substance P level, which is a useful predictive biomarker of aspiration. Thirty-four patients were included (mean age ± SD: 70.9 ± 10.8 years). A greater number of cigarettes/day and a higher antipsychotic dosage were found to be associated with a lower plasma substance P level, while age showed a trend-level effect. This finding suggests the need for intensive observation for prevention of aspiration pneumonia in heavy smokers who are receiving a higher antipsychotic dose in this senior population.

Original languageEnglish
Pages (from-to)526-528
Number of pages3
JournalPsychiatry and Clinical Neurosciences
Volume65
Issue number5
DOIs
Publication statusPublished - 2011 Aug

Fingerprint

Aspiration Pneumonia
Substance P
Antipsychotic Agents
Schizophrenia
Cross-Sectional Studies
Tobacco Products
Biomarkers
Observation
Demography
Health
Population
Aspirations (Psychology)

Keywords

  • antipsychotics
  • aspiration pneumonia
  • schizophrenia
  • smoking
  • substance P

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Plasma substance P level in patients with schizophrenia : A cross-sectional study. / Ishida, Takuto; Uchida, Hiroyuki; Suzuki, Takefumi; Nakajima, Shinichiro; Watanabe, Koichiro; Kashima, Haruo.

In: Psychiatry and Clinical Neurosciences, Vol. 65, No. 5, 08.2011, p. 526-528.

Research output: Contribution to journalArticle

Ishida, Takuto ; Uchida, Hiroyuki ; Suzuki, Takefumi ; Nakajima, Shinichiro ; Watanabe, Koichiro ; Kashima, Haruo. / Plasma substance P level in patients with schizophrenia : A cross-sectional study. In: Psychiatry and Clinical Neurosciences. 2011 ; Vol. 65, No. 5. pp. 526-528.
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