Plasminogen activators and plasminogen activator inhibitor 1 before and after venous occlusion of the upper limb in thromboangiitis obliterans (Buerger's disease)

N. A. Choudhury, M. H. Pietraszek, T. Hachiya, S. Baba, S. Sakaguchi, Y. Takada, A. Takada

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Plasma levels of plasminogen activators (t-PA, u-PA) and their inhibitor (PAI-1) were studied in patients suffering from Buerger's disease and healthy volunteers before and after 15 minutes of venous occlusion test. The baseline levels of t-PA in group of patients did not differ from those of controls. On the contrary patients with Buerger's disease showed a marked increase in u-PA antigen concentrations with concomitant decrease in PAI-1 antigen levels. During venous stasis t-PA antigen concentrations increased in all subjects, however it was much pronounced in controls. Venous occlusion resulted in significant decrease in free PAI-1 levels in the group of patients only. In conclusion, Buerger's disease is associated with the endothelial derangement with increased u-PA release and decreased PAI-1 release, which does not influence the function of fibrinolytic system. The fact that the reduced response of the endothelium to release t-PA after venous stasis goes in parallel with marked decrease in PAI-1 antigen levels seems to suggest that patients suffering from Buerger's disease are not at high risk of intravascular fibrin deposition.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalThrombosis Research
Volume66
Issue number4
DOIs
Publication statusPublished - 1992 May 15

Keywords

  • Buerger's disease
  • Plasminogen Activator Inhibitor 1
  • Plasminogen activators
  • venous occlusion

ASJC Scopus subject areas

  • Hematology

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