TY - JOUR
T1 - Pleiotropic effects of statins on acute kidney injury
T2 - involvement of Krüppel-like factor 4
AU - Yoshida, Tadashi
AU - Hayashi, Matsuhiko
N1 - Funding Information:
This study was supported by Grants-in-Aid for Scientific Research (KAKENHI) from Japan Society for the Promotion of Science to T.Y. (16K09655) and M.H. (15K09271) and grants from the Japanese Association of Dialysis Physicians (JADP Grant 2015-6) to T.Y. and the Kidney Foundation, Japan (JKFB15-7) to T.Y.
Publisher Copyright:
© 2016, Japanese Society of Nephrology.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Statins, the inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, are potent cholesterol-lowering drugs used for primary and secondary prevention of coronary artery disease. They also possess multiple beneficial effects independent of their cholesterol-lowering properties, which are called as their “pleiotropic” effects. The results of recent studies have revealed that statins exert their pleiotropic effects in the kidneys, in that they are protective against acute kidney injury (AKI). Moreover, Krüppel-like factor 4, a zinc-finger transcription factor, in endothelial cells has been identified as a novel mediator of statins. This article summarizes the pleiotropic effects of statins on AKI, and reviews the recent progress in our understanding of the regulatory mechanisms involved in statin-mediated protection against AKI.
AB - Statins, the inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, are potent cholesterol-lowering drugs used for primary and secondary prevention of coronary artery disease. They also possess multiple beneficial effects independent of their cholesterol-lowering properties, which are called as their “pleiotropic” effects. The results of recent studies have revealed that statins exert their pleiotropic effects in the kidneys, in that they are protective against acute kidney injury (AKI). Moreover, Krüppel-like factor 4, a zinc-finger transcription factor, in endothelial cells has been identified as a novel mediator of statins. This article summarizes the pleiotropic effects of statins on AKI, and reviews the recent progress in our understanding of the regulatory mechanisms involved in statin-mediated protection against AKI.
KW - 3-Hydroxy-3-methylglutaryl-coenzyme A
KW - Cholesterol
KW - Krüppel-like factors
KW - Pleiotropic effect
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U2 - 10.1007/s10157-016-1286-4
DO - 10.1007/s10157-016-1286-4
M3 - Article
C2 - 27294581
AN - SCOPUS:84974846105
SN - 1342-1751
VL - 21
SP - 175
EP - 181
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 2
ER -