Pneumocystis jiroveci pneumonia associated with low-dose methotrexate treatment for rheumatoid arthritis: Report of two cases and review of the literature

Yuko Kaneko, Akira Suwa, Yasuo Ikeda, Michito Hirakata

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Low-dose methotrexate (MTX) therapy is widely used for rheumatoid arthritis (RA) because of its favorable efficacy and toxicity profile. Although Pneumocystis jiroveci pneumonia (PCP) is most often seen in severely immunosuppressed patients, PCP complicating low-dose MTX therapy for RA has been reported to sometimes occur. We herein report two cases of patients who developed PCP during treatment with low-dose MTX, and discuss the importance of prophylaxis for this opportunistic infection.

Original languageEnglish
Pages (from-to)36-38
Number of pages3
JournalModern Rheumatology
Volume16
Issue number1
DOIs
Publication statusPublished - 2006 Feb

Fingerprint

Pneumocystis carinii
Pneumocystis Pneumonia
Methotrexate
Rheumatoid Arthritis
Opportunistic Infections
Therapeutics

Keywords

  • Methotrexate (MTX)
  • Pneumocystis jiroveci pneumonia (PCP)
  • Prophylaxis
  • Rheumatoid arthritis (RA)

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

@article{4c03be5055b74a9c98f1fcd75cad12eb,
title = "Pneumocystis jiroveci pneumonia associated with low-dose methotrexate treatment for rheumatoid arthritis: Report of two cases and review of the literature",
abstract = "Low-dose methotrexate (MTX) therapy is widely used for rheumatoid arthritis (RA) because of its favorable efficacy and toxicity profile. Although Pneumocystis jiroveci pneumonia (PCP) is most often seen in severely immunosuppressed patients, PCP complicating low-dose MTX therapy for RA has been reported to sometimes occur. We herein report two cases of patients who developed PCP during treatment with low-dose MTX, and discuss the importance of prophylaxis for this opportunistic infection.",
keywords = "Methotrexate (MTX), Pneumocystis jiroveci pneumonia (PCP), Prophylaxis, Rheumatoid arthritis (RA)",
author = "Yuko Kaneko and Akira Suwa and Yasuo Ikeda and Michito Hirakata",
year = "2006",
month = "2",
doi = "10.1007/s10165-005-0443-5",
language = "English",
volume = "16",
pages = "36--38",
journal = "Modern Rheumatology",
issn = "1439-7595",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - Pneumocystis jiroveci pneumonia associated with low-dose methotrexate treatment for rheumatoid arthritis

T2 - Report of two cases and review of the literature

AU - Kaneko, Yuko

AU - Suwa, Akira

AU - Ikeda, Yasuo

AU - Hirakata, Michito

PY - 2006/2

Y1 - 2006/2

N2 - Low-dose methotrexate (MTX) therapy is widely used for rheumatoid arthritis (RA) because of its favorable efficacy and toxicity profile. Although Pneumocystis jiroveci pneumonia (PCP) is most often seen in severely immunosuppressed patients, PCP complicating low-dose MTX therapy for RA has been reported to sometimes occur. We herein report two cases of patients who developed PCP during treatment with low-dose MTX, and discuss the importance of prophylaxis for this opportunistic infection.

AB - Low-dose methotrexate (MTX) therapy is widely used for rheumatoid arthritis (RA) because of its favorable efficacy and toxicity profile. Although Pneumocystis jiroveci pneumonia (PCP) is most often seen in severely immunosuppressed patients, PCP complicating low-dose MTX therapy for RA has been reported to sometimes occur. We herein report two cases of patients who developed PCP during treatment with low-dose MTX, and discuss the importance of prophylaxis for this opportunistic infection.

KW - Methotrexate (MTX)

KW - Pneumocystis jiroveci pneumonia (PCP)

KW - Prophylaxis

KW - Rheumatoid arthritis (RA)

UR - http://www.scopus.com/inward/record.url?scp=33644554773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644554773&partnerID=8YFLogxK

U2 - 10.1007/s10165-005-0443-5

DO - 10.1007/s10165-005-0443-5

M3 - Article

C2 - 16622722

AN - SCOPUS:33644554773

VL - 16

SP - 36

EP - 38

JO - Modern Rheumatology

JF - Modern Rheumatology

SN - 1439-7595

IS - 1

ER -