Pneumocystis jiroveci pneumonia associated with low-dose methotrexate treatment for rheumatoid arthritis: Report of two cases and review of the literature

Yuko Kaneko, Akira Suwa, Yasuo Ikeda, Michito Hirakata

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Low-dose methotrexate (MTX) therapy is widely used for rheumatoid arthritis (RA) because of its favorable efficacy and toxicity profile. Although Pneumocystis jiroveci pneumonia (PCP) is most often seen in severely immunosuppressed patients, PCP complicating low-dose MTX therapy for RA has been reported to sometimes occur. We herein report two cases of patients who developed PCP during treatment with low-dose MTX, and discuss the importance of prophylaxis for this opportunistic infection.

Original languageEnglish
Pages (from-to)36-38
Number of pages3
JournalModern rheumatology
Volume16
Issue number1
DOIs
Publication statusPublished - 2006 Feb 1

Keywords

  • Methotrexate (MTX)
  • Pneumocystis jiroveci pneumonia (PCP)
  • Prophylaxis
  • Rheumatoid arthritis (RA)

ASJC Scopus subject areas

  • Rheumatology

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