Pneumonitis induced by ou-gon (scullcap)

Kei Takeshita, Yoshifumi Saisho, Kumi Kitamura, Noriko Kaburagi, Tomohiro Funabiki, Toshiyuki Inamura, Yoshitaka Oyamada, Koichiro Asano, Kazuhiro Yamaguchi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A 53-year-old Japanese man with recurrent interstitial pneumonia was referred to us. The patient had taken a traditional herb medicine, otsu-ji-to, before the onset of pneumonia. A provocation test for each herbal ingredient contained in otsu-ji-to revealed that the pneumonitis had been induced by ou-gon (scullcap). Lymphocytosis with the CD8+ T-cell subset predominance was found in the bronchoalveolar lavage fluid and lymphocytic alveolitis was noted in the transbronchial lung biopsy specimen after the provocation test. Ou-gon, or scullcap, should be included in the list of drugs with definite causal association with pneumonitis.

Original languageEnglish
Pages (from-to)764-768
Number of pages5
JournalInternal Medicine
Volume40
Issue number8
DOIs
Publication statusPublished - 2001 Aug

Keywords

  • Drug-induced pneumonitis
  • Herb medicine

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Takeshita, K., Saisho, Y., Kitamura, K., Kaburagi, N., Funabiki, T., Inamura, T., Oyamada, Y., Asano, K., & Yamaguchi, K. (2001). Pneumonitis induced by ou-gon (scullcap). Internal Medicine, 40(8), 764-768. https://doi.org/10.2169/internalmedicine.40.764