Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma

Akikazu Kawase, Genichiro Ishii, Kanji Nagai, Takeo Ito, Tatsuya Nagano, Yukinori Murata, Tomoyuki Hishida, Mitsuyo Nishimura, Junji Yoshida, Kazuya Suzuki, Atsushi Ochiai

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Recent studies have reported increased podoplanin expression by cancer cells and stromal cells, but little is known about its expression and biological significance in adenocarcinoma of the lung. We examined podoplanin expression by both cancer cells and stromal cells in 177 consecutive lung adenocarcinoma cases and analyzed relations between podoplanin expression and both clinicopathological factors and outcome. Podoplanin expression was observed on the apical membrane of the cancer cells in only 9 of the 177 (5.1%) cases. By contrast, cancer-associated fibroblasts (CAFs) were found to express podoplanin in 54 cases (30.5%). Podoplanin (+) CAFs were found only in invasive adenocarcinoma and none were found in noninvasive adenocarcinoma. Conventional prognostic factors were significantly correlated with podoplanin expression by CAFs. The univariate analyses and log-rank test showed that podoplanin expression was significantly associated with shorter survival time (p < 0.001 and p < 0.001, respectively). We divided the cases into 3 groups according grade based on the proportion of CAFs expressing podoplanin [a grade 0 group (n = 123), a grade 1 group (n = 36) and a grade 2 group (n = 18)]. The result showed that conventional prognostic factors were significantly correlated with the grade of podoplanin expression by CAFs. Furthermore, the grade 2 group tended to have a shorter survival time than the grade 1 group (p = 0.092). The results of this study highlight the importance of podoplanin expression by CAFs and provide new insights into the biology of the cancer microenvironment in adenocarcinoma of the lung.

Original languageEnglish
Pages (from-to)1053-1059
Number of pages7
JournalInternational Journal of Cancer
Volume123
Issue number5
DOIs
Publication statusPublished - 2008 Sep 1
Externally publishedYes

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Stromal Cells
Adenocarcinoma
Neoplasms
Tumor Microenvironment
Cancer-Associated Fibroblasts
Adenocarcinoma of lung
Cell Membrane

Keywords

  • Cancer-associated fibroblasts
  • Lung adenocarcinoma
  • Podoplanin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Kawase, A., Ishii, G., Nagai, K., Ito, T., Nagano, T., Murata, Y., ... Ochiai, A. (2008). Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. International Journal of Cancer, 123(5), 1053-1059. https://doi.org/10.1002/ijc.23611

Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. / Kawase, Akikazu; Ishii, Genichiro; Nagai, Kanji; Ito, Takeo; Nagano, Tatsuya; Murata, Yukinori; Hishida, Tomoyuki; Nishimura, Mitsuyo; Yoshida, Junji; Suzuki, Kazuya; Ochiai, Atsushi.

In: International Journal of Cancer, Vol. 123, No. 5, 01.09.2008, p. 1053-1059.

Research output: Contribution to journalArticle

Kawase, A, Ishii, G, Nagai, K, Ito, T, Nagano, T, Murata, Y, Hishida, T, Nishimura, M, Yoshida, J, Suzuki, K & Ochiai, A 2008, 'Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma', International Journal of Cancer, vol. 123, no. 5, pp. 1053-1059. https://doi.org/10.1002/ijc.23611
Kawase, Akikazu ; Ishii, Genichiro ; Nagai, Kanji ; Ito, Takeo ; Nagano, Tatsuya ; Murata, Yukinori ; Hishida, Tomoyuki ; Nishimura, Mitsuyo ; Yoshida, Junji ; Suzuki, Kazuya ; Ochiai, Atsushi. / Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. In: International Journal of Cancer. 2008 ; Vol. 123, No. 5. pp. 1053-1059.
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