Abstract
Background: The prognostic significance of the tumor microenvironment, which is created by both cancer cells and cancer-associated fibroblasts (CAFs), has been increasingly recognized. The purpose of this study was to analyze the prognostic markers of stage I squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both cancer cells and CAFs. Methods: A total of 142 patients with stage I SqCC were included in this study. We examined the expressions of E-cadherin, laminin-5, podoplanin, c-MET, carbonic anhydrase IX (CA-IX), CD10, and CD44 in the cancer cells and those of podoplanin, CA-IX, CD10, and CD44 in the CAFs to evaluate their prognostic value. Results: Patients with low E-cadherin expression in the cancer cells showed a significantly poorer prognosis than those with high E-cadherin expression in the cancer cells (P <.001). On the other hand, high podoplanin expression in the CAFs was also associated with a significantly poorer prognosis (P <.001). A multivariate analysis identified low E-cadherin expression in the cancer cells and high podoplanin expression in the CAFs as significantly independent prognostic factors for overall survival (P =.013 and P =.0011, respectively). According to subgroup analyses combining E-cadherin expression in cancer cells and podoplanin expression in CAFs, 5-year overall survival of patients with low E-cadherin expression in the cancer cells and high podoplanin expression in the CAFs was 7.0% and showed a significantly poorer prognosis as compared with other groups (P <.001). Conclusions: The current study indicates that immunophenotypes of CAFs could have a prognostic value independent of those of the cancer cells in SqCC.
| Original language | English |
|---|---|
| Pages (from-to) | 963-970 |
| Number of pages | 8 |
| Journal | Chest |
| Volume | 143 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
- Cardiology and Cardiovascular Medicine
Cite this
Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma : Usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phenotype. / Ono, Shotaro; Ishii, Genichiro; Nagai, Kanji; Takuwa, Teruhisa; Yoshida, Junji; Nishimura, Mitsuyo; Hishida, Tomoyuki; Aokage, Keiju; Fujii, Satoshi; Ikeda, Norihiko; Ochiai, Atsushi.
In: Chest, Vol. 143, No. 4, 2013, p. 963-970.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma
T2 - Usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phenotype
AU - Ono, Shotaro
AU - Ishii, Genichiro
AU - Nagai, Kanji
AU - Takuwa, Teruhisa
AU - Yoshida, Junji
AU - Nishimura, Mitsuyo
AU - Hishida, Tomoyuki
AU - Aokage, Keiju
AU - Fujii, Satoshi
AU - Ikeda, Norihiko
AU - Ochiai, Atsushi
PY - 2013
Y1 - 2013
N2 - Background: The prognostic significance of the tumor microenvironment, which is created by both cancer cells and cancer-associated fibroblasts (CAFs), has been increasingly recognized. The purpose of this study was to analyze the prognostic markers of stage I squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both cancer cells and CAFs. Methods: A total of 142 patients with stage I SqCC were included in this study. We examined the expressions of E-cadherin, laminin-5, podoplanin, c-MET, carbonic anhydrase IX (CA-IX), CD10, and CD44 in the cancer cells and those of podoplanin, CA-IX, CD10, and CD44 in the CAFs to evaluate their prognostic value. Results: Patients with low E-cadherin expression in the cancer cells showed a significantly poorer prognosis than those with high E-cadherin expression in the cancer cells (P <.001). On the other hand, high podoplanin expression in the CAFs was also associated with a significantly poorer prognosis (P <.001). A multivariate analysis identified low E-cadherin expression in the cancer cells and high podoplanin expression in the CAFs as significantly independent prognostic factors for overall survival (P =.013 and P =.0011, respectively). According to subgroup analyses combining E-cadherin expression in cancer cells and podoplanin expression in CAFs, 5-year overall survival of patients with low E-cadherin expression in the cancer cells and high podoplanin expression in the CAFs was 7.0% and showed a significantly poorer prognosis as compared with other groups (P <.001). Conclusions: The current study indicates that immunophenotypes of CAFs could have a prognostic value independent of those of the cancer cells in SqCC.
AB - Background: The prognostic significance of the tumor microenvironment, which is created by both cancer cells and cancer-associated fibroblasts (CAFs), has been increasingly recognized. The purpose of this study was to analyze the prognostic markers of stage I squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both cancer cells and CAFs. Methods: A total of 142 patients with stage I SqCC were included in this study. We examined the expressions of E-cadherin, laminin-5, podoplanin, c-MET, carbonic anhydrase IX (CA-IX), CD10, and CD44 in the cancer cells and those of podoplanin, CA-IX, CD10, and CD44 in the CAFs to evaluate their prognostic value. Results: Patients with low E-cadherin expression in the cancer cells showed a significantly poorer prognosis than those with high E-cadherin expression in the cancer cells (P <.001). On the other hand, high podoplanin expression in the CAFs was also associated with a significantly poorer prognosis (P <.001). A multivariate analysis identified low E-cadherin expression in the cancer cells and high podoplanin expression in the CAFs as significantly independent prognostic factors for overall survival (P =.013 and P =.0011, respectively). According to subgroup analyses combining E-cadherin expression in cancer cells and podoplanin expression in CAFs, 5-year overall survival of patients with low E-cadherin expression in the cancer cells and high podoplanin expression in the CAFs was 7.0% and showed a significantly poorer prognosis as compared with other groups (P <.001). Conclusions: The current study indicates that immunophenotypes of CAFs could have a prognostic value independent of those of the cancer cells in SqCC.
UR - http://www.scopus.com/inward/record.url?scp=84876012210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876012210&partnerID=8YFLogxK
U2 - 10.1378/chest.12-0913
DO - 10.1378/chest.12-0913
M3 - Article
C2 - 23081722
AN - SCOPUS:84876012210
VL - 143
SP - 963
EP - 970
JO - Chest
JF - Chest
SN - 0012-3692
IS - 4
ER -