Poisson property of the occurrence of flip-flops in a model membrane

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

How do lipid molecules in membranes perform a flip-flop? The flip-flops of lipid molecules play a crucial role in the formation and flexibility of membranes. However, little has been determined about the behavior of flip-flops, either experimentally, or in molecular dynamics simulations. Here, we provide numerical results of the flip-flops of model lipid molecules in a model membrane and investigate the statistical properties, using millisecond-order coarse-grained molecular simulations (dissipative particle dynamics). We find that there are three different ways of flip-flops, which can be clearly characterized by their paths on the free energy surface. Furthermore, we found that the probability of the number of the flip-flops is well fitted by the Poisson distribution, and the probability density function for the inter-occurrence times of flip-flops coincides with that of the forward recurrence times. These results indicate that the occurrence of flip-flops is a Poisson process, which will play an important role in the flexibilities of membranes.

Original languageEnglish
Article number064901
JournalJournal of Chemical Physics
Volume140
Issue number6
DOIs
Publication statusPublished - 2014

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flip-flops
Flip flop circuits
occurrences
membranes
Membranes
Lipids
Poisson Distribution
lipids
Molecular Dynamics Simulation
Molecules
flexibility
poisson process
molecules
Recurrence
Poisson distribution
probability density functions
Probability density function
Free energy
Molecular dynamics
simulation

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry
  • Medicine(all)

Cite this

Poisson property of the occurrence of flip-flops in a model membrane. / Arai, Noriyoshi; Akimoto, Takuma; Yamamoto, Eiji; Yasui, Masato; Yasuoka, Kenji.

In: Journal of Chemical Physics, Vol. 140, No. 6, 064901, 2014.

Research output: Contribution to journalArticle

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