Abstract
Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabrication of electrospun nanofibers made of antithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activity of the MPC nanofibers. Moreover, the drug release was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC nanofibers retained excellent hemocompatibility and that the micro-patterned DLC efficiently controlled the drug-release rate of MPC fibers.
Original language | English |
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Pages (from-to) | 51-55 |
Number of pages | 5 |
Journal | Journal of Biorheology |
Volume | 29 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- DLC
- Drug-release
- Electrospinning
- MPC
- Nanofibers
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering