Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release

Kenta Bito; Tomoki Maeda; Katsuya Hagiwara; Soki Yoshida; Terumitsu Hasebe; Atsushi Hotta

doi:10.17106/jbr.29.51

Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release

Kenta Bito, Tomoki Maeda, Katsuya Hagiwara, Soki Yoshida, Terumitsu Hasebe, Atsushi Hotta

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabrication of electrospun nanofibers made of antithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activity of the MPC nanofibers. Moreover, the drug release was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC nanofibers retained excellent hemocompatibility and that the micro-patterned DLC efficiently controlled the drug-release rate of MPC fibers.

Original language	English
Pages (from-to)	51-55
Number of pages	5
Journal	Journal of Biorheology
Volume	29
Issue number	1
DOIs	https://doi.org/10.17106/jbr.29.51
Publication status	Published - 2015

Keywords

DLC
Drug-release
Electrospinning
MPC
Nanofibers

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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title = "Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release",

abstract = "Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabrication of electrospun nanofibers made of antithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activity of the MPC nanofibers. Moreover, the drug release was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC nanofibers retained excellent hemocompatibility and that the micro-patterned DLC efficiently controlled the drug-release rate of MPC fibers.",

keywords = "DLC, Drug-release, Electrospinning, MPC, Nanofibers",

author = "Kenta Bito and Tomoki Maeda and Katsuya Hagiwara and Soki Yoshida and Terumitsu Hasebe and Atsushi Hotta",

note = "Funding Information: Acknowledgements This work was supported in part by JSPS KAK-ENHI Grant Numbers 23360294 and 24656395 to A.H., and by MEXT Grant-in-Aid for the Program for Leading Graduate Schools to T.M. Funding Information: This work was supported in part by JSPS KAKENHI Grant Numbers 23360294 and 24656395 to A.H., and by MEXT Grant-in-Aid for the Program for Leading Graduate Schools to T.M. Publisher Copyright: {\textcopyright} Japanese Society of Biorheology 2015.",

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language = "English",

volume = "29",

pages = "51--55",

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AU - Bito, Kenta

AU - Maeda, Tomoki

AU - Hagiwara, Katsuya

AU - Yoshida, Soki

AU - Hasebe, Terumitsu

AU - Hotta, Atsushi

N1 - Funding Information: Acknowledgements This work was supported in part by JSPS KAK-ENHI Grant Numbers 23360294 and 24656395 to A.H., and by MEXT Grant-in-Aid for the Program for Leading Graduate Schools to T.M. Funding Information: This work was supported in part by JSPS KAKENHI Grant Numbers 23360294 and 24656395 to A.H., and by MEXT Grant-in-Aid for the Program for Leading Graduate Schools to T.M. Publisher Copyright: © Japanese Society of Biorheology 2015.

PY - 2015

Y1 - 2015

N2 - Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabrication of electrospun nanofibers made of antithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activity of the MPC nanofibers. Moreover, the drug release was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC nanofibers retained excellent hemocompatibility and that the micro-patterned DLC efficiently controlled the drug-release rate of MPC fibers.

AB - Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabrication of electrospun nanofibers made of antithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activity of the MPC nanofibers. Moreover, the drug release was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC nanofibers retained excellent hemocompatibility and that the micro-patterned DLC efficiently controlled the drug-release rate of MPC fibers.

KW - DLC

KW - Drug-release

KW - Electrospinning

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KW - Nanofibers

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Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release

Abstract

Keywords

ASJC Scopus subject areas

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