Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release

Kenta Bito, Tomoki Maeda, Katsuya Hagiwara, Soki Yoshida, Terumitsu Hasebe, Atsushi Hotta

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabrication of electrospun nanofibers made of antithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activity of the MPC nanofibers. Moreover, the drug release was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC nanofibers retained excellent hemocompatibility and that the micro-patterned DLC efficiently controlled the drug-release rate of MPC fibers.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalJournal of Biorheology
Volume29
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • DLC
  • Drug-release
  • Electrospinning
  • MPC
  • Nanofibers

ASJC Scopus subject areas

  • Mechanics of Materials
  • Materials Science(all)
  • Mechanical Engineering

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