Polyarthralgia suggests poor prognosis in systemic sclerosis with both pulmonary fibrosis and anti-DNA topoisomerase I antibodies

J. Kaburaki, M. Kuwana, Y. Okano, M. Hirakata, T. Tojo, Y. Ikeda

Research output: Contribution to journalArticle

Abstract

Clinical features were studied in patients with systemic sclerosis (SSc) who had both pulmonary fibrosis and anti-DNA topoisomerase I antibodies, and who ultimately died of this organ involvement. The subjects consisted of 62 patients with SSc. Medical records were retrospectively reviewed. The frequency of polyarthralgia was significantly higher in these patients than in other SSc patients. However, the frequency of positive reaction of rheumatoid factor was not significantly different. These results suggested that polyarthralgia as fibrotic change in the skin and contracture shows a poor prognosis in these SSc patients.

Original languageEnglish
Pages (from-to)317-318
Number of pages2
JournalConnective Tissue
Volume26
Issue number4
Publication statusPublished - 1994 Dec 1
Externally publishedYes

Keywords

  • anti-DNA topoisomerase I antibodies
  • polyarthralgia
  • pulmonary fibrosis
  • systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology

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