Polymer entrapment in polymerized silicate for preparing highly stable capillary coatings for CE and CE-MS

Maria Rowena N. Monton, Masaru Tomita, Tomoyoshi Soga, Yasushi Ishihama

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An easy-to-implement capillary coating strategy based on polymer entrapment in the network of polymerized silicate is described. In this manner, cationic polymers are tightiy fixed onto the inner wall of the capillary for electroosmotic flow control without necessitating complex surface modification chemistries. The resulting coated capillary exhibited good stability over a wide range of pH, good reproducibility, strong endurance in more than 300 electrophoretic runs, and tolerance of commonly employed organic solvent additives in CE. Applications in CE-MS analysis of biologically important anions as well as sample enrichment are shown. Additionally, it was used as a durable base for attachment of multiple layers of charged polymers on the wall, via electrostatic interaction with the preceding layer. Thus, two novel types of highly stable coated capillaries, one with anodic EOF and the other cathodic, were developed.

Original languageEnglish
Pages (from-to)7838-7844
Number of pages7
JournalAnalytical chemistry
Volume79
Issue number20
DOIs
Publication statusPublished - 2007 Oct 15

ASJC Scopus subject areas

  • Analytical Chemistry

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