Polymorphism of β-adrenergic receptors and susceptibility of open-angle glaucoma

Yoko Inagaki, Yukihiko Mashima, Nobuo Fuse, Tomoyo Funayama, Yuichiro Ohtake, Noriko Yasuda, Akira Murakami, Yoshihiro Hotta, Takeo Fukuchi, Kazuo Tsubota

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25 Citations (Scopus)

Abstract

Purpose: The human trabecular meshwork and ciliary body, which express β-adrenergic receptors (ADRB1 and ADRB2), control aqueous humor dynamics. We investigated associations of ADRB polymorphisms with open-angle glaucoma (OAG), because ADRB gene polymorphisms alter receptor function. Methods: We studied 240 Japanese controls and 505 Japanese OAG patients including 211 with primary open-angle glaucoma (POAG), and 294 with normal-tension glaucoma (NTG). Associations of four polymorphisms (Ser49Gly and Arg389Gly in the ADRB1 gene; Arg16Gly and Gln27Glu in the ADRB2 gene) were compared between patients and controls. Age, intraocular pressure (IOP), and visual field defects at diagnosis were examined for associations with polymorphisms. Results: The Arg389Gly polymorphism in the ADRB1 gene showed significantly different allele and genotype frequencies in patients with NTG than in controls (p=0.004 and 0.006, respectively). Other polymorphisms did not show a significant frequency difference. In POAG patients, carriers of Gly16 in the ADRB2 gene were significantly younger at diagnosis than noncarriers (p<0.001). The IOP at diagnosis was significantly higher in OAG patients carrying 27Glu in the ADRB2 gene than in patients without this allele (p<0.001). Clinical characteristics of OAG patients did not differ significantly in relation to other polymorphisms. Conclusions: Certain polymorphisms of the ADRB1 and ADRB 2 genes influence the pathophysiology of OAG in Japanese patients.

Original languageEnglish
Pages (from-to)673-680
Number of pages8
JournalMolecular vision
Volume12
Publication statusPublished - 2006 Jun 12

ASJC Scopus subject areas

  • Ophthalmology

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    Inagaki, Y., Mashima, Y., Fuse, N., Funayama, T., Ohtake, Y., Yasuda, N., Murakami, A., Hotta, Y., Fukuchi, T., & Tsubota, K. (2006). Polymorphism of β-adrenergic receptors and susceptibility of open-angle glaucoma. Molecular vision, 12, 673-680.