Polymorphism of β-adrenergic receptors and susceptibility of open-angle glaucoma

Yoko Inagaki, Yukihiko Mashima, Nobuo Fuse, Tomoyo Funayama, Yuichiro Ohtake, Noriko Yasuda, Akira Murakami, Yoshihiro Hotta, Takeo Fukuchi, Kazuo Tsubota

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Purpose: The human trabecular meshwork and ciliary body, which express β-adrenergic receptors (ADRB1 and ADRB2), control aqueous humor dynamics. We investigated associations of ADRB polymorphisms with open-angle glaucoma (OAG), because ADRB gene polymorphisms alter receptor function. Methods: We studied 240 Japanese controls and 505 Japanese OAG patients including 211 with primary open-angle glaucoma (POAG), and 294 with normal-tension glaucoma (NTG). Associations of four polymorphisms (Ser49Gly and Arg389Gly in the ADRB1 gene; Arg16Gly and Gln27Glu in the ADRB2 gene) were compared between patients and controls. Age, intraocular pressure (IOP), and visual field defects at diagnosis were examined for associations with polymorphisms. Results: The Arg389Gly polymorphism in the ADRB1 gene showed significantly different allele and genotype frequencies in patients with NTG than in controls (p=0.004 and 0.006, respectively). Other polymorphisms did not show a significant frequency difference. In POAG patients, carriers of Gly16 in the ADRB2 gene were significantly younger at diagnosis than noncarriers (p<0.001). The IOP at diagnosis was significantly higher in OAG patients carrying 27Glu in the ADRB2 gene than in patients without this allele (p<0.001). Clinical characteristics of OAG patients did not differ significantly in relation to other polymorphisms. Conclusions: Certain polymorphisms of the ADRB1 and ADRB 2 genes influence the pathophysiology of OAG in Japanese patients.

Original languageEnglish
Pages (from-to)673-680
Number of pages8
JournalMolecular Vision
Volume12
Publication statusPublished - 2006 Jun 12

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Open Angle Glaucoma
Adrenergic Receptors
Genes
Low Tension Glaucoma
Intraocular Pressure
Trabecular Meshwork
Ciliary Body
Aqueous Humor
Visual Fields
Gene Frequency
Alleles
Genotype

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Inagaki, Y., Mashima, Y., Fuse, N., Funayama, T., Ohtake, Y., Yasuda, N., ... Tsubota, K. (2006). Polymorphism of β-adrenergic receptors and susceptibility of open-angle glaucoma. Molecular Vision, 12, 673-680.

Polymorphism of β-adrenergic receptors and susceptibility of open-angle glaucoma. / Inagaki, Yoko; Mashima, Yukihiko; Fuse, Nobuo; Funayama, Tomoyo; Ohtake, Yuichiro; Yasuda, Noriko; Murakami, Akira; Hotta, Yoshihiro; Fukuchi, Takeo; Tsubota, Kazuo.

In: Molecular Vision, Vol. 12, 12.06.2006, p. 673-680.

Research output: Contribution to journalArticle

Inagaki, Y, Mashima, Y, Fuse, N, Funayama, T, Ohtake, Y, Yasuda, N, Murakami, A, Hotta, Y, Fukuchi, T & Tsubota, K 2006, 'Polymorphism of β-adrenergic receptors and susceptibility of open-angle glaucoma', Molecular Vision, vol. 12, pp. 673-680.
Inagaki Y, Mashima Y, Fuse N, Funayama T, Ohtake Y, Yasuda N et al. Polymorphism of β-adrenergic receptors and susceptibility of open-angle glaucoma. Molecular Vision. 2006 Jun 12;12:673-680.
Inagaki, Yoko ; Mashima, Yukihiko ; Fuse, Nobuo ; Funayama, Tomoyo ; Ohtake, Yuichiro ; Yasuda, Noriko ; Murakami, Akira ; Hotta, Yoshihiro ; Fukuchi, Takeo ; Tsubota, Kazuo. / Polymorphism of β-adrenergic receptors and susceptibility of open-angle glaucoma. In: Molecular Vision. 2006 ; Vol. 12. pp. 673-680.
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AU - Yasuda, Noriko

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