Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)

Tomohiro Honda, Yukihiko Dan, Noriko Koyabu, Hisakazu Ohtani, Yasufumi Sawada, Ichiro Ieiri, Kenji Otsubo, Shun Higuchi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5' -ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.

Original languageEnglish
Pages (from-to)479-481
Number of pages3
JournalDrug Metabolism and Pharmacokinetics
Volume17
Issue number5
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

MDR Genes
Amino Acid Substitution
Single Nucleotide Polymorphism
Healthy Volunteers
Homozygote
Multiple Drug Resistance
P-Glycoprotein
Heterozygote
Exons

Keywords

  • amino acid substitution
  • exon 5
  • G325A
  • multidrug-resistance 1 (P-glycoprotein, MDR1, ABCB1)
  • single nucleotide polymorphism (SNP)

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Polymorphism of MDR1 Gene in Healthy Japanese Subjects : A Novel SNP with an Amino Acid Substitution (Glu108Lys). / Honda, Tomohiro; Dan, Yukihiko; Koyabu, Noriko; Ohtani, Hisakazu; Sawada, Yasufumi; Ieiri, Ichiro; Otsubo, Kenji; Higuchi, Shun.

In: Drug Metabolism and Pharmacokinetics, Vol. 17, No. 5, 2002, p. 479-481.

Research output: Contribution to journalArticle

Honda, Tomohiro ; Dan, Yukihiko ; Koyabu, Noriko ; Ohtani, Hisakazu ; Sawada, Yasufumi ; Ieiri, Ichiro ; Otsubo, Kenji ; Higuchi, Shun. / Polymorphism of MDR1 Gene in Healthy Japanese Subjects : A Novel SNP with an Amino Acid Substitution (Glu108Lys). In: Drug Metabolism and Pharmacokinetics. 2002 ; Vol. 17, No. 5. pp. 479-481.
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AU - Sawada, Yasufumi

AU - Ieiri, Ichiro

AU - Otsubo, Kenji

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