Polymorphism of Tau Fibrils

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tau is a protein that binds and stabilizes microtubules as a physiologic function, but it is also well known as a protein that forms insoluble and fibrillar aggregates in neurodegenerative diseases called tauopathies. Notably, pathologic Tau fibrils exhibit various morphologies that are associated with particular subtypes of tauopathies. Distinct symptoms among tauopathies could thus be regulated by the morphology/structure of Tau fibrils, but the exact mechanism by which such polymorphism arises in Tau fibrils remains unknown. In this chapter, to help the reader understand possible roles of polymorphic Tau fibrils in the pathomechanism of neurodegenerative diseases, I review and summarize several factors affecting the morphologies of Tau fibrils in vitro.

Original languageEnglish
Title of host publicationBio-nanoimaging
Subtitle of host publicationProtein Misfolding and Aggregation
PublisherElsevier Inc.
Pages213-222
Number of pages10
ISBN (Print)9780123944313
DOIs
Publication statusPublished - 2013 Nov 1

    Fingerprint

Keywords

  • Disulfide formation
  • Neurodegenerative diseases
  • Polymorphism
  • Protein aggregation
  • Protein fibrillation
  • Tau
  • Tauopathies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Furukawa, Y. (2013). Polymorphism of Tau Fibrils. In Bio-nanoimaging: Protein Misfolding and Aggregation (pp. 213-222). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394431-3.00019-5