Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease

S. Higuchi, T. Muramatsu, H. Arai, M. Hayashida, H. Sasaki, J. Q. Trojanowski

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Disturbances of the dopamine system are involved in the pathogenesis of idiopathic Parkinson's disease (PD). Although genetic factors may play a role in the etiology of PD, there is little direct evidence implicating a specific gene. We conducted a study to test the hypothesis that allelic variations of the dopamine receptors (D2, D3, D4) and the dopamine transporter (DAT) contribute to the susceptibility to PD. Association analyses of 70 Japanese PD patients and the same number of age-matched controls did not reveal any association between alleles of the D2, D3 or D4 receptor genes or the DAT gene and PD. Thus, our results suggest that factor(s) other than allelic variations of these key proteins in the dopamine system contribute to the susceptibility to PD.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalJournal of Neural Transmission - Parkinson's Disease and Dementia Section
Volume10
Issue number2-3
DOIs
Publication statusPublished - 1995 Jun 1

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Keywords

  • Parkinson's disease
  • dopamine D2 receptor
  • dopamine D3 receptor
  • dopamine D4 receptor
  • dopamine transporter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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