Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus

H. Nakashima, M. Akahoshi, Y. Tanaka, Kunihiro Yamaoka, E. Ogami, S. Nagano, Y. Arinobu, H. Niiro, T. Otsuka, Y. Niho

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective. To assess the association between polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) and systemic erythematosus (SLE) in Japanese people. Method. We examined the IL-10 receptor genotype of 109 SLE patients and 102 healthy subjects by the reverse transcription-polymerase chain reaction-restriction fragment length polymorphism (RT-PCR-RFLP) method. Results. There was no difference in the IL10R genotype frequencies of these two groups. Conclusion. The IL10R genotype does not determine susceptibility to SLE in Japanese people.

Original languageEnglish
Pages (from-to)1142-1144
Number of pages3
JournalRheumatology
Volume38
Issue number11
Publication statusPublished - 1999 Nov
Externally publishedYes

Fingerprint

Interleukin-10 Receptors
Systemic Lupus Erythematosus
Complementary DNA
Genotype
Genes
Gene Frequency
Restriction Fragment Length Polymorphisms
Reverse Transcription
Healthy Volunteers
Polymerase Chain Reaction

Keywords

  • IL-10
  • IL-10 receptor gene (IL10R)
  • Polymorphism
  • Susceptibility
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Nakashima, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., ... Niho, Y. (1999). Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus. Rheumatology, 38(11), 1142-1144.

Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus. / Nakashima, H.; Akahoshi, M.; Tanaka, Y.; Yamaoka, Kunihiro; Ogami, E.; Nagano, S.; Arinobu, Y.; Niiro, H.; Otsuka, T.; Niho, Y.

In: Rheumatology, Vol. 38, No. 11, 11.1999, p. 1142-1144.

Research output: Contribution to journalArticle

Nakashima, H, Akahoshi, M, Tanaka, Y, Yamaoka, K, Ogami, E, Nagano, S, Arinobu, Y, Niiro, H, Otsuka, T & Niho, Y 1999, 'Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus', Rheumatology, vol. 38, no. 11, pp. 1142-1144.
Nakashima H, Akahoshi M, Tanaka Y, Yamaoka K, Ogami E, Nagano S et al. Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus. Rheumatology. 1999 Nov;38(11):1142-1144.
Nakashima, H. ; Akahoshi, M. ; Tanaka, Y. ; Yamaoka, Kunihiro ; Ogami, E. ; Nagano, S. ; Arinobu, Y. ; Niiro, H. ; Otsuka, T. ; Niho, Y. / Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus. In: Rheumatology. 1999 ; Vol. 38, No. 11. pp. 1142-1144.
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