Poly(N-isopropylacrylamide) based thermoresponsive polymer brushes for bioseparation, cellular tissue fabrication, and nano actuators

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Many thermoresponsive surfaces for biomedical applications have been developed using various techniques for modifying substrates with thermoresponsive polymers. In addition, surface-initiated living radical polymerization methods such as atom-transfer radical polymerization (ATRP) and reversible addition–fragmentation chain-transfer (RAFT) polymerization have been developed as nano structure controlled surface modification methods for modifying thermoresponsive polymers to substrates. These polymerization techniques allow the accurate control of polymerization and the formation of densely packed polymer brush structures. The present review article summarizes a variety of thermoresponsive polymer brushes, mainly comprising poly(N-isopropylacrylamide) (PIPAAm), prepared by surface-initiated ATRP and RAFT polymerization. Self-oscillating polymer brushes as new nano-actuators are also discussed.

Original languageEnglish
Pages (from-to)9-23
Number of pages15
JournalNano-Structures and Nano-Objects
Volume16
DOIs
Publication statusPublished - 2018 Oct 1

Fingerprint

brushes
Brushes
Polymers
Actuators
polymerization
actuators
Tissue
Fabrication
fabrication
Polymerization
polymers
Atom transfer radical polymerization
Living polymerization
Substrates
Free radical polymerization
Surface treatment
poly-N-isopropylacrylamide
atoms

Keywords

  • Bioseparation
  • Regenerative medicine
  • Surface modification
  • Thermoresponsive surface
  • Tissue engineering

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

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title = "Poly(N-isopropylacrylamide) based thermoresponsive polymer brushes for bioseparation, cellular tissue fabrication, and nano actuators",
abstract = "Many thermoresponsive surfaces for biomedical applications have been developed using various techniques for modifying substrates with thermoresponsive polymers. In addition, surface-initiated living radical polymerization methods such as atom-transfer radical polymerization (ATRP) and reversible addition–fragmentation chain-transfer (RAFT) polymerization have been developed as nano structure controlled surface modification methods for modifying thermoresponsive polymers to substrates. These polymerization techniques allow the accurate control of polymerization and the formation of densely packed polymer brush structures. The present review article summarizes a variety of thermoresponsive polymer brushes, mainly comprising poly(N-isopropylacrylamide) (PIPAAm), prepared by surface-initiated ATRP and RAFT polymerization. Self-oscillating polymer brushes as new nano-actuators are also discussed.",
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author = "Kenichi Nagase and Teruo Okano and Hideko Kanazawa",
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T1 - Poly(N-isopropylacrylamide) based thermoresponsive polymer brushes for bioseparation, cellular tissue fabrication, and nano actuators

AU - Nagase, Kenichi

AU - Okano, Teruo

AU - Kanazawa, Hideko

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Many thermoresponsive surfaces for biomedical applications have been developed using various techniques for modifying substrates with thermoresponsive polymers. In addition, surface-initiated living radical polymerization methods such as atom-transfer radical polymerization (ATRP) and reversible addition–fragmentation chain-transfer (RAFT) polymerization have been developed as nano structure controlled surface modification methods for modifying thermoresponsive polymers to substrates. These polymerization techniques allow the accurate control of polymerization and the formation of densely packed polymer brush structures. The present review article summarizes a variety of thermoresponsive polymer brushes, mainly comprising poly(N-isopropylacrylamide) (PIPAAm), prepared by surface-initiated ATRP and RAFT polymerization. Self-oscillating polymer brushes as new nano-actuators are also discussed.

AB - Many thermoresponsive surfaces for biomedical applications have been developed using various techniques for modifying substrates with thermoresponsive polymers. In addition, surface-initiated living radical polymerization methods such as atom-transfer radical polymerization (ATRP) and reversible addition–fragmentation chain-transfer (RAFT) polymerization have been developed as nano structure controlled surface modification methods for modifying thermoresponsive polymers to substrates. These polymerization techniques allow the accurate control of polymerization and the formation of densely packed polymer brush structures. The present review article summarizes a variety of thermoresponsive polymer brushes, mainly comprising poly(N-isopropylacrylamide) (PIPAAm), prepared by surface-initiated ATRP and RAFT polymerization. Self-oscillating polymer brushes as new nano-actuators are also discussed.

KW - Bioseparation

KW - Regenerative medicine

KW - Surface modification

KW - Thermoresponsive surface

KW - Tissue engineering

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