Polysaccharide-Coated Liposomal Amphotericin B for the Treatment of Murine Pulmonary Candidiasis

Takashige Miyazaki, Shigeru Kohno, Kazuo Sasayama, Yuichi Inoue, Kohei Hara, Masayoshi Ogasawara, Toshinori Sato, Junzo Sunamoto

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Abstract

Amylopectin-coated liposomal amphotericin B was investigated in a murine model of pulmonary candidiasis. The LD50 of amylopectin-coated liposomal amphotericin B in normal mice was more than 10.0 mg/kg, and that of conventional amphotericin B was 1.2 mg/kg. Amylopectin-coated liposomes showed twice the concentration in the lungs of conventional liposomes. Candida albicans was inoculated intratracheally into BALB/C mice. Twenty-four hours later, the number of Candida in the lungs of mice treated with amylopectin-coated liposomes was less than in those treated with conventional liposomes, and amylopectin-coated liposomes improved the survival rate of inoculated mice. Coating liposomes with amylopectin aids the targeting of amphotericin B to the lungs.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalTohoku Journal of Experimental Medicine
Volume168
Issue number3
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

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Keywords

  • HPLC
  • amphotericin B
  • amylopectin
  • liposome
  • pulmonary candidiasis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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