Abstract
Amylopectin-coated liposomal amphotericin B was investigated in a murine model of pulmonary candidiasis. The LD50 of amylopectin-coated liposomal amphotericin B in normal mice was more than 10.0 mg/kg, and that of conventional amphotericin B was 1.2 mg/kg. Amylopectin-coated liposomes showed twice the concentration in the lungs of conventional liposomes. Candida albicans was inoculated intratracheally into BALB/C mice. Twenty-four hours later, the number of Candida in the lungs of mice treated with amylopectin-coated liposomes was less than in those treated with conventional liposomes, and amylopectin-coated liposomes improved the survival rate of inoculated mice. Coating liposomes with amylopectin aids the targeting of amphotericin B to the lungs.
Original language | English |
---|---|
Pages (from-to) | 483-490 |
Number of pages | 8 |
Journal | Tohoku Journal of Experimental Medicine |
Volume | 168 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1992 |
Keywords
- HPLC
- amphotericin B
- amylopectin
- liposome
- pulmonary candidiasis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)