Polysaccharide-Coated Liposome with Antimicrobial Agents Against Intracytoplasmic Pathogen and Fungus

Shigeru Kohno, Takashige Miyazaki, Keizo Yamaguchi, Hikaru Tanaka, Toshiaki Hayashi, Masaki Hirota, Atsushi Saito, Kohei Hara, Toshinori Sato, Junzo Sunamoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Liposomes which are stabilized by being coated with polysaccharides such as amylopectin and mannan are concentrated in the lung and liver more than simple liposomes without any polysaccharide-coat. These polysaccharidecoated liposomes are easily internalized by macrophages. Amylopectin-coated liposome with ceftazidime (survival rate, 30%) was better than free ceftazidime alone (survival rate, 0%) for the treatment of Legionella pneumonia in guinea pigs. The antibiotic efficacy rate of polysaccharide-coated liposome bearing minocycline (MINO) or ampicillin (ABPC) was much better than that of free MINO or ABPC for the treatment of Listeria infection. These data suggest that polysaccharide-coated liposomes bearing antibiotics are excellent for intracytoplasmic pathogen especially in the reticuloendothelial system where a large population of phagocytes exist.

Original languageEnglish
Pages (from-to)137-147
Number of pages11
JournalJournal of Bioactive and Compatible Polymers
Volume3
Issue number2
DOIs
Publication statusPublished - 1988 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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    Kohno, S., Miyazaki, T., Yamaguchi, K., Tanaka, H., Hayashi, T., Hirota, M., Saito, A., Hara, K., Sato, T., & Sunamoto, J. (1988). Polysaccharide-Coated Liposome with Antimicrobial Agents Against Intracytoplasmic Pathogen and Fungus. Journal of Bioactive and Compatible Polymers, 3(2), 137-147. https://doi.org/10.1177/088391158800300204