Polysaccharide-coated liposome with antimicrobial agents against intracytoplasmic pathogen and fungus

S. Kohno, T. Miyazaki, K. Yamaguchi, H. Tanaka, T. Hayashi, M. Hirota, A. Saito, K. Hara, Toshinori Sato, J. Sunamoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Liposomes which are stabilized by being coated with polysaccharides such as amylopectin and mannan are concentrated in the lung and liver more than simple liposomes without any polysaccharide-coat. These polysaccharide-coated liposomes are easily internalized by macrophages. Amylopectin-coated liposome with ceftazidime (survival rate, 30%) was better than free ceftazidime alone (survival rate, 0%) for the treatment of Legionella pneumonia in guinea pigs. The antibiotic efficacy rate of polysaccharide-coated liposome bearing minocycline (MINO) or ampicillin (ABPC) was much better than that of free MINO or ABPC for the treatment of Listeria infection. These data suggest that polysaccharide-coated liposomes bearing antibiotics are excellent for intracytoplasmic pathogen especially in the reticuloendothelial system where a large population of phagocytes exist. The toxicity of amphotericin B (AmpB) was reduced by encapsulation in polysaccharide-coated liposomes. Amylopectin-coated liposome with AmpB showed better efficacy rate (100%) against murine pulmonary candidiasis than the conventional liposome with AmpB (50%). The administration of amylopectin-coated liposomes with AmpB could be a viable choice for the treatment of pulmonary fungal diseases in human.

Original languageEnglish
Pages (from-to)137-147
Number of pages11
JournalJournal of Bioactive and Compatible Polymers
Volume3
Issue number2
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Antimicrobial agents
Liposomes
Pathogens
Polysaccharides
Anti-Infective Agents
Fungi
Amylopectins
Amylopectin
Amphotericin B
Bearings (structural)
Minocycline
Ceftazidime
Antibiotics
Fungal Lung Diseases
Anti-Bacterial Agents
Listeria
Mannans
Legionella
Listeriosis
Lung

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Kohno, S., Miyazaki, T., Yamaguchi, K., Tanaka, H., Hayashi, T., Hirota, M., ... Sunamoto, J. (1988). Polysaccharide-coated liposome with antimicrobial agents against intracytoplasmic pathogen and fungus. Journal of Bioactive and Compatible Polymers, 3(2), 137-147.

Polysaccharide-coated liposome with antimicrobial agents against intracytoplasmic pathogen and fungus. / Kohno, S.; Miyazaki, T.; Yamaguchi, K.; Tanaka, H.; Hayashi, T.; Hirota, M.; Saito, A.; Hara, K.; Sato, Toshinori; Sunamoto, J.

In: Journal of Bioactive and Compatible Polymers, Vol. 3, No. 2, 1988, p. 137-147.

Research output: Contribution to journalArticle

Kohno, S, Miyazaki, T, Yamaguchi, K, Tanaka, H, Hayashi, T, Hirota, M, Saito, A, Hara, K, Sato, T & Sunamoto, J 1988, 'Polysaccharide-coated liposome with antimicrobial agents against intracytoplasmic pathogen and fungus', Journal of Bioactive and Compatible Polymers, vol. 3, no. 2, pp. 137-147.
Kohno, S. ; Miyazaki, T. ; Yamaguchi, K. ; Tanaka, H. ; Hayashi, T. ; Hirota, M. ; Saito, A. ; Hara, K. ; Sato, Toshinori ; Sunamoto, J. / Polysaccharide-coated liposome with antimicrobial agents against intracytoplasmic pathogen and fungus. In: Journal of Bioactive and Compatible Polymers. 1988 ; Vol. 3, No. 2. pp. 137-147.
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