Polyurethane surface modification by graft polymerization of acrylamide for reduced protein adsorption and platelet adhesion

Keiji Fujimoto, Hideki Tadokoro, Yohichi Ueda, Yoshito Ikada

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Surface modification of polyurethane by glow-discharge treatment and subsequent graft polymerization of acrylamide was studied. The modified hydrophilic surfaces were characterized by the measurements of dynamic contact angle and ζ potentials and examined for protein adsorption behaviour and platelet adhesion. Data from in vitro and ex vivo experiments indicated a reduction of protein adsorption and platelet adhesion for the hydrophillic graft polymers, the extent of which was correlated to polymer graft density.

Original languageEnglish
Pages (from-to)442-448
Number of pages7
JournalBiomaterials
Volume14
Issue number6
DOIs
Publication statusPublished - 1993 May
Externally publishedYes

Keywords

  • Surface modification
  • graft polymerization
  • platelet adhesion
  • protein adsorption

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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