Polyurethane surface modification by graft polymerization of acrylamide for reduced protein adsorption and platelet adhesion

Keiji Fujimoto, Hideki Tadokoro, Yohichi Ueda, Yoshito Ikada

Research output: Contribution to journalArticle

91 Citations (Scopus)


Surface modification of polyurethane by glow-discharge treatment and subsequent graft polymerization of acrylamide was studied. The modified hydrophilic surfaces were characterized by the measurements of dynamic contact angle and ζ potentials and examined for protein adsorption behaviour and platelet adhesion. Data from in vitro and ex vivo experiments indicated a reduction of protein adsorption and platelet adhesion for the hydrophillic graft polymers, the extent of which was correlated to polymer graft density.

Original languageEnglish
Pages (from-to)442-448
Number of pages7
Issue number6
Publication statusPublished - 1993
Externally publishedYes



  • graft polymerization
  • platelet adhesion
  • protein adsorption
  • Surface modification

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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