Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient

Kanoko Egashira, Etsuko Fukuda, Takayuki Onga, Yasuo Yogi, Fukuzou Matsuya, Noriko Koyabu, Hisakazu Ohtani, Yasufumi Sawada

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background. Tacrolimus, an immunosuppressive agent, is widely used in patients after transplantation to prevent allograft rejection. Because tacrolimus has a narrow therapeutic range, it is essential to carefully control the blood level. It has been demonstrated that tacrolimus is metabolized mainly by cytochrome P-450 (CYP) 3A4, and that tacrolimus is a substrate of P-glycoprotein. Methods. This article reports a case of considerable increase in the blood level of tacrolimus after the intake of pomelo in a renal transplant recipient. Results. Pomelo may increase the blood concentration of tacrolimus by inhibiting CYP 3A4, P-glycoprotein, or both. Conclusions. Patients taking drugs such as tacrolimus or cyclosporine, which have their kinetics affected by grapefruit juice, should avoid pomelo and other grapefruit-related citrus fruits.

Original languageEnglish
Pages (from-to)1057
Number of pages1
JournalTransplantation
Volume75
Issue number7
Publication statusPublished - 2003 Apr 15
Externally publishedYes

Fingerprint

Tacrolimus
Transplants
Kidney
Citrus paradisi
P-Glycoprotein
Cytochrome P-450 Enzyme System
Citrus
Immunosuppressive Agents
Cyclosporine
Allografts
Transplantation
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Egashira, K., Fukuda, E., Onga, T., Yogi, Y., Matsuya, F., Koyabu, N., ... Sawada, Y. (2003). Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient. Transplantation, 75(7), 1057.

Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient. / Egashira, Kanoko; Fukuda, Etsuko; Onga, Takayuki; Yogi, Yasuo; Matsuya, Fukuzou; Koyabu, Noriko; Ohtani, Hisakazu; Sawada, Yasufumi.

In: Transplantation, Vol. 75, No. 7, 15.04.2003, p. 1057.

Research output: Contribution to journalArticle

Egashira, K, Fukuda, E, Onga, T, Yogi, Y, Matsuya, F, Koyabu, N, Ohtani, H & Sawada, Y 2003, 'Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient', Transplantation, vol. 75, no. 7, pp. 1057.
Egashira K, Fukuda E, Onga T, Yogi Y, Matsuya F, Koyabu N et al. Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient. Transplantation. 2003 Apr 15;75(7):1057.
Egashira, Kanoko ; Fukuda, Etsuko ; Onga, Takayuki ; Yogi, Yasuo ; Matsuya, Fukuzou ; Koyabu, Noriko ; Ohtani, Hisakazu ; Sawada, Yasufumi. / Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient. In: Transplantation. 2003 ; Vol. 75, No. 7. pp. 1057.
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AU - Ohtani, Hisakazu

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