Abstract
Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (< 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the follow-up duration to > 5 years. Conclusion: Being overweight/obese, combined with low TC levels, was strongly associated with liver cancer-related mortality in the EPOCH-JAPAN.
| Original language | English |
|---|---|
| Pages (from-to) | 2089-2095 |
| Number of pages | 7 |
| Journal | Asian Pacific Journal of Cancer Prevention |
| Volume | 19 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2018 Aug 1 |
Fingerprint
Keywords
- Body mass index
- Cholesterol
- Liver cancer
- Obesity
- Pooled analysis
ASJC Scopus subject areas
- Epidemiology
- Oncology
- Public Health, Environmental and Occupational Health
- Cancer Research
Cite this
Pooled analysis of the associations between body mass index, total cholesterol, and liver cancer-related mortality in Japan. / EPOCH-JAPAN Research Group.
In: Asian Pacific Journal of Cancer Prevention, Vol. 19, No. 8, 01.08.2018, p. 2089-2095.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pooled analysis of the associations between body mass index, total cholesterol, and liver cancer-related mortality in Japan
AU - EPOCH-JAPAN Research Group
AU - Ukawa, Shigekazu
AU - Tamakoshi, Akiko
AU - Murakami, Yoshitaka
AU - Kiyohara, Yutaka
AU - Yamada, Michiko
AU - Nagai, Masato
AU - Satoh, Atsushi
AU - Miura, Katsuyuki
AU - Ueshima, Hirotsugu
AU - Okamura, Tomonori
AU - Imai, Yutaka
AU - Ohkubo, Takayoshi
AU - Irie, Fujiko
AU - Iso, Hiroyasu
AU - Kitamura, Akihiko
AU - Ninomiya, Toshiharu
AU - Nakagawa, Hideaki
AU - Nakayama, Takeo
AU - Okayama, Akira
AU - Sairenchi, Toshimi
AU - Saitoh, Shigeyuki
AU - Sakata, Kiyomi
AU - Tsuji, Ichiro
AU - Kiyama, Masahiko
AU - Miyamoto, Yoshihiro
AU - Ishikawa, Shizukiyo
AU - Yatsuya, Hiroshi
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (< 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the follow-up duration to > 5 years. Conclusion: Being overweight/obese, combined with low TC levels, was strongly associated with liver cancer-related mortality in the EPOCH-JAPAN.
AB - Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (< 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the follow-up duration to > 5 years. Conclusion: Being overweight/obese, combined with low TC levels, was strongly associated with liver cancer-related mortality in the EPOCH-JAPAN.
KW - Body mass index
KW - Cholesterol
KW - Liver cancer
KW - Obesity
KW - Pooled analysis
UR - http://www.scopus.com/inward/record.url?scp=85052098696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052098696&partnerID=8YFLogxK
U2 - 10.22034/APJCP.2018.19.8.2089
DO - 10.22034/APJCP.2018.19.8.2089
M3 - Article
C2 - 30139206
AN - SCOPUS:85052098696
VL - 19
SP - 2089
EP - 2095
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
SN - 1513-7368
IS - 8
ER -