@article{b11443ac00a64c819c34d8580b9a27af,
title = "Pooled analysis of the associations between body mass index, total cholesterol, and liver cancer-related mortality in Japan",
abstract = "Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (< 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the follow-up duration to > 5 years. Conclusion: Being overweight/obese, combined with low TC levels, was strongly associated with liver cancer-related mortality in the EPOCH-JAPAN.",
keywords = "Body mass index, Cholesterol, Liver cancer, Obesity, Pooled analysis",
author = "{EPOCH-JAPAN Research Group} and Shigekazu Ukawa and Akiko Tamakoshi and Yoshitaka Murakami and Yutaka Kiyohara and Michiko Yamada and Masato Nagai and Atsushi Satoh and Katsuyuki Miura and Hirotsugu Ueshima and Tomonori Okamura and Yutaka Imai and Takayoshi Ohkubo and Fujiko Irie and Hiroyasu Iso and Akihiko Kitamura and Toshiharu Ninomiya and Hideaki Nakagawa and Takeo Nakayama and Akira Okayama and Toshimi Sairenchi and Shigeyuki Saitoh and Kiyomi Sakata and Ichiro Tsuji and Masahiko Kiyama and Yoshihiro Miyamoto and Shizukiyo Ishikawa and Hiroshi Yatsuya",
note = "Funding Information: This research was supported by a grant-in-aid from the Ministry of Health, Labour and Welfare, Health and Labor Sciences research grants, Japan (Research on Health Services: H17-Kenkou-007; Comprehensive Research on Cardiovascular Disease and Life-Related Disease: H18-Junkankitou[Seishuu]-Ippan-012; Comprehensive Research on Cardiovascular Disease and Life-Related Disease: H19-Junkankitou [Seishuu]-Ippan-012; Comprehensive Research on Cardiovascular and Life-Style Related Diseases: H20-Junkankitou [Seishuu]-Ippan-013; Comprehensive Research on Cardiovascular and Life-Style Related Diseases: H23-Junkankitou [Seishuu]-Ippan-005); an Intramural Research Fund (22-4-5) for Cardiovascular Diseases of National Cerebral and Cardiovascular Center; Comprehensive Research on Cardiovascular and Life-Style Related Diseases (H26-Junkankitou [Seisaku]-Ippan-001) and H29-Junkankitou [Seishuu]-Ippan-003). We are grateful to all of the participants of each cohort study. We thank Mrs. Toshimi Yoshida (Shiga University of Medical Science) and Mrs. Satoko Narikawa (Keio University) for expert clerical assistance. The Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group is composed of the following investigators. Chairperson: Hirotsugu Ueshima (Shiga University of Medical Science); Co-Chairperson: Tomonori Okamura (Keio University School of Medicine); Executive committee: Hirotsugu Ueshima (Shiga University of Medical Science), Yutaka Imai (Tohoku Institute for Management of Blood Pressure), Takayoshi Ohkubo (Teikyo University School of Medicine), Fujiko Irie (Ibaraki Prefecture), Hiroyasu Iso (Osaka University Graduate School of Medicine), Akihiko Kitamura (Tokyo Metropolitan Institute of Gerontology), Toshiharu Ninomiya (Kyushu University Graduate School of Medicine), Yutaka Kiyohara (Hisayama Health C&C Center), Katsuyuki Miura (Shiga University of Medical Science), Yoshitaka Murakami (Toho University), Hideaki Nakagawa (Kanazawa Medical University), Takeo Nakayama (Kyoto University School of Public Health), Akira Okayama (Research Institute of Strategy for Prevention), Toshimi Sairenchi (Dokkyo Medical University), Shigeyuki Saitoh (Sapporo Medical University), Kiyomi Sakata (Iwate Medical University), Akiko Tamakoshi (Hokkaido University Faculty of Medicine), Ichiro Tsuji (Tohoku University Graduate School of Medicine), Michiko Yamada (Radiation Effects Research Foundation), Masahiko Kiyama (Osaka Center for Cancer and Cardiovascular Disease Prevention), Yoshihiro Miyamoto (National Cerebral and Cardiovascular Center), Shizukiyo Ishikawa (Jichi Medical University), Hiroshi Yatsuya (Fujita Health University), and Tomonori Okamura (Keio University School of Medicine). Publisher Copyright: {\textcopyright} 2018 Asian Pacific Organization for Cancer Prevention.",
year = "2018",
month = aug,
day = "1",
doi = "10.22034/APJCP.2018.19.8.2089",
language = "English",
volume = "19",
pages = "2089--2095",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "8",
}
