TY - JOUR
T1 - Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder
AU - Kodaira, Masaki
AU - Iwadare, Yoshitaka
AU - Ushijima, Hirokage
AU - Oiji, Arata
AU - Kato, Motoichiro
AU - Sugiyama, Nobuhiro
AU - Sasayama, Daimei
AU - Usami, Masahide
AU - Watanabe, Kyota
AU - Saito, Kazuhiko
N1 - Funding Information:
This study was funded by a Research Grant for Nervous and Mental Disorders (20B-6) from the Japanese Ministry of Health, Labour, and Welfare.
PY - 2012/10/12
Y1 - 2012/10/12
N2 - Background: Several lines of evidence implicate orbitofrontal cortex dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD). The purpose of this study was to investigate neuropsychological dysfunction of the orbitofrontal cortex in children with OCD.Methods: The Iowa Gambling Task (IGT), which reflects orbitofrontal cortex function, and the Wisconsin Card Sorting Test (WCST), which is associated with functioning of the dorsolateral prefrontal cortex, were administered to 22 children with OCD and 22 healthy controls matched for gender, age, and intelligence.Results: OCD patients displayed poor performance on the IGT. In contrast, performance on the WCST was not impaired in OCD patients compared to controls.Conclusions: These findings are in line with previous studies demonstrating that OCD in childhood is associated with a dysfunction of orbitofrontal-striatal-thalamic circuitry.
AB - Background: Several lines of evidence implicate orbitofrontal cortex dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD). The purpose of this study was to investigate neuropsychological dysfunction of the orbitofrontal cortex in children with OCD.Methods: The Iowa Gambling Task (IGT), which reflects orbitofrontal cortex function, and the Wisconsin Card Sorting Test (WCST), which is associated with functioning of the dorsolateral prefrontal cortex, were administered to 22 children with OCD and 22 healthy controls matched for gender, age, and intelligence.Results: OCD patients displayed poor performance on the IGT. In contrast, performance on the WCST was not impaired in OCD patients compared to controls.Conclusions: These findings are in line with previous studies demonstrating that OCD in childhood is associated with a dysfunction of orbitofrontal-striatal-thalamic circuitry.
KW - Childhood-onset
KW - Iowa gambling task
KW - Obsessive-compulsive disorder
KW - Orbitofrontal cortex
KW - Wisconsin card sorting test
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U2 - 10.1186/1744-859X-11-25
DO - 10.1186/1744-859X-11-25
M3 - Article
C2 - 23062199
AN - SCOPUS:84867306267
SN - 1744-859X
VL - 11
JO - Annals of General Psychiatry
JF - Annals of General Psychiatry
M1 - 25
ER -
