Poorly differentiated hepatocellular carcinoma accompanied by anti-Hu antibody-positive paraneoplastic peripheral neuropathy

Takahiro Matsui, Yumiko Hori, Hiroaki Nagano, Hidetoshi Eguchi, Shigeru Marubashi, Hiroshi Wada, Naoki Wada, Jun ichiro Ikeda, Michiie Sakamoto, Eiichi Morii

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The anti-Hu antibody is one of the most famous onco-neural antibodies related to paraneoplastic neurological syndrome, and is associated with small cell lung carcinoma in most cases. Here, we report a case of poorly differentiated hepatocellular carcinoma accompanied by paraneoplastic peripheral neuropathy positive for the anti-Hu antibody. Image inspection before operation revealed that no tumors were found in organs other than the liver, including lung, and that the liver tumor had no metastatic lesion. The liver tumor showed histological appearance of poorly differentiated carcinoma with cartilaginous metaplasia and partial blastoid cell appearance. Most tumor cells presented trabecular-like structure lined by sinusoidal vessels. Immunohistochemically, the tumor cells were positive for low molecular weight cytokeratin and vimentin, partially positive for cytokeratin 19 and CD56, but negative for synaptophysin, chromogranin A and alpha-fetoprotein. Based on the trabecular-like morphology and the results of immunohistochemical staining, we concluded that the tumor was diagnosed as poorly differentiated hepatocellular carcinoma. Anti-Hu antibody-positive paraneoplastic peripheral neuropathy accompanied with liver tumor is extremely rare as far as is known. The presented case indicates that poorly differentiated carcinoma has the potential to be the responsible lesion of anti-Hu antibody-positive paraneoplastic neurological syndrome and systemic work-up is important for the management of this neurological disorder.

Original languageEnglish
Pages (from-to)388-392
Number of pages5
JournalPathology International
Volume65
Issue number7
DOIs
Publication statusPublished - 2015 Jul 1

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Paraneoplastic Polyneuropathy
Anti-Idiotypic Antibodies
Hepatocellular Carcinoma
Neoplasms
Paraneoplastic Syndromes
Liver
Keratin-19
Carcinoma
Chromogranin A
Synaptophysin
Small Cell Lung Carcinoma
Metaplasia
alpha-Fetoproteins
Vimentin
Keratins
Nervous System Diseases
Molecular Weight
Staining and Labeling
Lung

Keywords

  • Anti-Hu antibody
  • Paraneoplastic neurological syndrome
  • Poorly differentiated hepatocellular carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Poorly differentiated hepatocellular carcinoma accompanied by anti-Hu antibody-positive paraneoplastic peripheral neuropathy. / Matsui, Takahiro; Hori, Yumiko; Nagano, Hiroaki; Eguchi, Hidetoshi; Marubashi, Shigeru; Wada, Hiroshi; Wada, Naoki; Ikeda, Jun ichiro; Sakamoto, Michiie; Morii, Eiichi.

In: Pathology International, Vol. 65, No. 7, 01.07.2015, p. 388-392.

Research output: Contribution to journalArticle

Matsui, T, Hori, Y, Nagano, H, Eguchi, H, Marubashi, S, Wada, H, Wada, N, Ikeda, JI, Sakamoto, M & Morii, E 2015, 'Poorly differentiated hepatocellular carcinoma accompanied by anti-Hu antibody-positive paraneoplastic peripheral neuropathy', Pathology International, vol. 65, no. 7, pp. 388-392. https://doi.org/10.1111/pin.12304
Matsui, Takahiro ; Hori, Yumiko ; Nagano, Hiroaki ; Eguchi, Hidetoshi ; Marubashi, Shigeru ; Wada, Hiroshi ; Wada, Naoki ; Ikeda, Jun ichiro ; Sakamoto, Michiie ; Morii, Eiichi. / Poorly differentiated hepatocellular carcinoma accompanied by anti-Hu antibody-positive paraneoplastic peripheral neuropathy. In: Pathology International. 2015 ; Vol. 65, No. 7. pp. 388-392.
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