TY - JOUR
T1 - Population attributable numbers and fractions of deaths due to smoking
T2 - A pooled analysis of 180,000 Japanese
AU - Murakami, Yoshitaka
AU - Miura, Katsuyuki
AU - Okamura, Tomonori
AU - Ueshima, Hirotsugu
N1 - Funding Information:
This research was supported by a Grant-in-Aid from the Ministry of Health, Labor and Welfare, Health and Labor Sciences Research Grants, Japan (Research on Health Services: H17-Kenkou-007; Comprehensive Research on Cardiovascular and Life-Style Related Diseases: H18-Junkankitou [Seishuu]-Ippan-012; and Comprehensive Research on Cardiovascular and Life-Style Related Diseases: H20-Junkankitou [Seishuu]-Ippan-013). YM was supported by the Banyu Fellowship Program of Banyu Life Science Foundation International.
PY - 2011/1
Y1 - 2011/1
N2 - Objective: Age- and sex-specific population attributable fraction (PAF) and premature deaths attributable to smoking were estimated from a pooled analysis of cohort studies in Japan. Methods: A pooled analysis of individual participant data from 13 well-qualified cohort studies throughout Japan (a total of 183,251 Japanese aged 40-89, 69,502 men and 113,749 women; the baseline years between 1987 and 1995 with average 10 years of follow-up) was performed. Poison regression model was used to estimate age- and sex-specific hazard ratios, and their PAFs of all-cause deaths and number of annual premature deaths attributable to smoking were estimated. Results: Overall PAF attributable to smoking was 24.6% in men and 6.0% in women. The estimated number of annual premature deaths due to smoking was 121,854 (men: 109,998; women: 11,856) in Japan. The age-specific PAF was largest in men aged 60-69 (47.7%) and in women aged 50-59 (12.2%). In the older group aged 70-79 and 80-89, PAF was 15.4% and 8.0% in men and 3.5% and 1.5% in women, respectively. Conclusions: Age-specific PAFs attributable to smoking in Japanese men are much larger than that reported from other Asian countries.
AB - Objective: Age- and sex-specific population attributable fraction (PAF) and premature deaths attributable to smoking were estimated from a pooled analysis of cohort studies in Japan. Methods: A pooled analysis of individual participant data from 13 well-qualified cohort studies throughout Japan (a total of 183,251 Japanese aged 40-89, 69,502 men and 113,749 women; the baseline years between 1987 and 1995 with average 10 years of follow-up) was performed. Poison regression model was used to estimate age- and sex-specific hazard ratios, and their PAFs of all-cause deaths and number of annual premature deaths attributable to smoking were estimated. Results: Overall PAF attributable to smoking was 24.6% in men and 6.0% in women. The estimated number of annual premature deaths due to smoking was 121,854 (men: 109,998; women: 11,856) in Japan. The age-specific PAF was largest in men aged 60-69 (47.7%) and in women aged 50-59 (12.2%). In the older group aged 70-79 and 80-89, PAF was 15.4% and 8.0% in men and 3.5% and 1.5% in women, respectively. Conclusions: Age-specific PAFs attributable to smoking in Japanese men are much larger than that reported from other Asian countries.
KW - Pooled analysis
KW - Population attributable fraction
KW - Smoking
KW - Total mortality
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U2 - 10.1016/j.ypmed.2010.11.009
DO - 10.1016/j.ypmed.2010.11.009
M3 - Article
C2 - 21111753
AN - SCOPUS:78650542958
SN - 0091-7435
VL - 52
SP - 60
EP - 65
JO - Preventive Medicine
JF - Preventive Medicine
IS - 1
ER -
