Population-based cohort study assessing the efficacy of cervical cytology (Pap smear) and human papillomavirus (HPV) testing as modalities for cervical cancer screening

Toru Morisada, Kumiko Saika, Eiko Saito, Kanako Kono, Hiroshi Saito, Daisuke Aoki

Research output: Contribution to journalArticle

Abstract

In cervical cancer screening, several trials have shown that human papillomavirus (HPV) testing or combined HPV testing and cytology leads to earlier detection of cervical intraepithelial neoplasia Grade 3 or worse (CIN3+) compared with cytology alone. However, the availability of similar evidence in our country remains limited. In 2013, 34 local governments were selected to administer a cervical cancer screening program utilizing either cytology alone or in combination with HPV testing. We planned a cohort study to assess the effectiveness of HPV testing as a modality for cervical cancer screening. The primary outcome of this study was the incidence of CIN3+ in each group, as well as to assess the risks and benefits of receiving screening for women in both groups. These results will contribute to elucidating the details of the positive and negative impacts of introducing HPV testing into a population-based cervical cancer screening program in Japan.

Original languageEnglish
Pages (from-to)495-498
Number of pages4
JournalJapanese Journal of Clinical Oncology
Volume48
Issue number5
DOIs
Publication statusPublished - 2018 May 1

Fingerprint

Papanicolaou Test
Early Detection of Cancer
Uterine Cervical Neoplasms
Cell Biology
Cohort Studies
Population
Local Government
Cervical Intraepithelial Neoplasia
Japan
Outcome Assessment (Health Care)
Incidence

Keywords

  • Cervical cancer
  • Cytology
  • HPV testing
  • Screening

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Population-based cohort study assessing the efficacy of cervical cytology (Pap smear) and human papillomavirus (HPV) testing as modalities for cervical cancer screening. / Morisada, Toru; Saika, Kumiko; Saito, Eiko; Kono, Kanako; Saito, Hiroshi; Aoki, Daisuke.

In: Japanese Journal of Clinical Oncology, Vol. 48, No. 5, 01.05.2018, p. 495-498.

Research output: Contribution to journalArticle

@article{159a5a9294be42fba8f1160b330773c3,
title = "Population-based cohort study assessing the efficacy of cervical cytology (Pap smear) and human papillomavirus (HPV) testing as modalities for cervical cancer screening",
abstract = "In cervical cancer screening, several trials have shown that human papillomavirus (HPV) testing or combined HPV testing and cytology leads to earlier detection of cervical intraepithelial neoplasia Grade 3 or worse (CIN3+) compared with cytology alone. However, the availability of similar evidence in our country remains limited. In 2013, 34 local governments were selected to administer a cervical cancer screening program utilizing either cytology alone or in combination with HPV testing. We planned a cohort study to assess the effectiveness of HPV testing as a modality for cervical cancer screening. The primary outcome of this study was the incidence of CIN3+ in each group, as well as to assess the risks and benefits of receiving screening for women in both groups. These results will contribute to elucidating the details of the positive and negative impacts of introducing HPV testing into a population-based cervical cancer screening program in Japan.",
keywords = "Cervical cancer, Cytology, HPV testing, Screening",
author = "Toru Morisada and Kumiko Saika and Eiko Saito and Kanako Kono and Hiroshi Saito and Daisuke Aoki",
year = "2018",
month = "5",
day = "1",
doi = "10.1093/jjco/hyy025",
language = "English",
volume = "48",
pages = "495--498",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Population-based cohort study assessing the efficacy of cervical cytology (Pap smear) and human papillomavirus (HPV) testing as modalities for cervical cancer screening

AU - Morisada, Toru

AU - Saika, Kumiko

AU - Saito, Eiko

AU - Kono, Kanako

AU - Saito, Hiroshi

AU - Aoki, Daisuke

PY - 2018/5/1

Y1 - 2018/5/1

N2 - In cervical cancer screening, several trials have shown that human papillomavirus (HPV) testing or combined HPV testing and cytology leads to earlier detection of cervical intraepithelial neoplasia Grade 3 or worse (CIN3+) compared with cytology alone. However, the availability of similar evidence in our country remains limited. In 2013, 34 local governments were selected to administer a cervical cancer screening program utilizing either cytology alone or in combination with HPV testing. We planned a cohort study to assess the effectiveness of HPV testing as a modality for cervical cancer screening. The primary outcome of this study was the incidence of CIN3+ in each group, as well as to assess the risks and benefits of receiving screening for women in both groups. These results will contribute to elucidating the details of the positive and negative impacts of introducing HPV testing into a population-based cervical cancer screening program in Japan.

AB - In cervical cancer screening, several trials have shown that human papillomavirus (HPV) testing or combined HPV testing and cytology leads to earlier detection of cervical intraepithelial neoplasia Grade 3 or worse (CIN3+) compared with cytology alone. However, the availability of similar evidence in our country remains limited. In 2013, 34 local governments were selected to administer a cervical cancer screening program utilizing either cytology alone or in combination with HPV testing. We planned a cohort study to assess the effectiveness of HPV testing as a modality for cervical cancer screening. The primary outcome of this study was the incidence of CIN3+ in each group, as well as to assess the risks and benefits of receiving screening for women in both groups. These results will contribute to elucidating the details of the positive and negative impacts of introducing HPV testing into a population-based cervical cancer screening program in Japan.

KW - Cervical cancer

KW - Cytology

KW - HPV testing

KW - Screening

UR - http://www.scopus.com/inward/record.url?scp=85047900297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047900297&partnerID=8YFLogxK

U2 - 10.1093/jjco/hyy025

DO - 10.1093/jjco/hyy025

M3 - Article

C2 - 30535331

AN - SCOPUS:85047900297

VL - 48

SP - 495

EP - 498

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 5

ER -