Population stochasticity, random determination of handedness, and the genetic basis of antisymmetry

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Conspicuous lateral asymmetries of organisms are classified into two major categories: antisymmetry (AS), characterized by almost equal frequencies of dextral and sinistral morphs, and directional asymmetry (DA), in which one morph dominates. I compared and characterized two types of genes, both with existing examples, in their roles in the evolutionary transitions between AS and DA for the first time. Handedness genes (HGs) determine the chirality in a strict sense, while randomization genes (RGs) randomize the chirality. A theory predicts that, in an AS population maintained by HGs under negative frequency-dependent selection, RGs harness fluctuation of the morph frequencies as their driving force and thus increase their frequency until half of the population flips the phenotype. These predictions were confirmed by simulations. Consequently, RGs mask the genetic effects of HGs, which provides a possible explanation for the apparent lack of a genetic basis for AS in empirical AS studies.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalJournal of Theoretical Biology
Volume290
Issue number1
DOIs
Publication statusPublished - 2011 Dec 7

Fingerprint

Functional Laterality
Stochasticity
Genes
Gene
Population
Random Allocation
Randomisation
genes
Asymmetry
Chirality
harness
Flip
Driving Force
Masks
morphs
Phenotype
Empirical Study
Mask
Lateral
Fluctuations

Keywords

  • Asymmetry
  • Chirality
  • Frequency-dependent selection

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Modelling and Simulation
  • Statistics and Probability
  • Applied Mathematics

Cite this

Population stochasticity, random determination of handedness, and the genetic basis of antisymmetry. / Kamimura, Yoshitaka.

In: Journal of Theoretical Biology, Vol. 290, No. 1, 07.12.2011, p. 73-80.

Research output: Contribution to journalArticle

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