TY - JOUR
T1 - Porous ceramics of β-tricalcium phosphate composed of rod-shaped particles is highly biodegradable and expresses prominent osteoconductivity
AU - Okuda, Takatoshi
AU - Yonezawa, Ikuho
AU - Ioku, Koji
AU - Minagi, Hideyuki
AU - Kurosawa, Hisashi
AU - Ikeda, Tohru
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Newly developed porous β-tricalcium phosphate composed of rod-shaped particles was grafted into distal end of the left femur of female Japan White rabbit. As a control, hydrixyapatite generated in the same size was grafted. In both implants, 350μm in diameter-sized holes were created vertically and horizontally. Three weeks after grafting, margin of the β-tricalcium phosphate was absorbed by osteoclasts and bone formation was seen near the absorbed region. Twenty-four weeks after grafting, more than 80% of the β-tricalcium phosphate was absorbed and newly formed bone was prominently observed. The hydroxyapatite was not remarkably absorbed even 24 weeks after grafting, and newly formed bone was observed only in the holes created in the implants. These results suggest that porous β-tricalcium phosphate composed of rod-shaped particles has highly biodegradable and osteoconductive nature, and appropriate to bone graft substitute.
AB - Newly developed porous β-tricalcium phosphate composed of rod-shaped particles was grafted into distal end of the left femur of female Japan White rabbit. As a control, hydrixyapatite generated in the same size was grafted. In both implants, 350μm in diameter-sized holes were created vertically and horizontally. Three weeks after grafting, margin of the β-tricalcium phosphate was absorbed by osteoclasts and bone formation was seen near the absorbed region. Twenty-four weeks after grafting, more than 80% of the β-tricalcium phosphate was absorbed and newly formed bone was prominently observed. The hydroxyapatite was not remarkably absorbed even 24 weeks after grafting, and newly formed bone was observed only in the holes created in the implants. These results suggest that porous β-tricalcium phosphate composed of rod-shaped particles has highly biodegradable and osteoconductive nature, and appropriate to bone graft substitute.
KW - Beta tricalcium phosphate
KW - Bone graft
KW - Hydroxyapatite
UR - http://www.scopus.com/inward/record.url?scp=33645336542&partnerID=8YFLogxK
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U2 - 10.4028/0-87849-992-x.1063
DO - 10.4028/0-87849-992-x.1063
M3 - Article
AN - SCOPUS:33645336542
SN - 1013-9826
VL - 309-311 II
SP - 1063
EP - 1066
JO - Key Engineering Materials
JF - Key Engineering Materials
ER -