Porous polyurethane tubes as vascular graft.

Keiji Fujimoto, M. Minato, S. Miyamoto, T. Kaneko, H. Kikuchi, K. Sakai, M. Okada, Y. Ikada

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A vascular graft with the inner diameter of about 3 mm was prepared from segmented poly (ether urethane) with an extrusion technique. To make the wall of the vascular grafts porous, NaCl salts were added to the polyurethane solution to be extruded and removed with water extraction after evaporating the solvent in the extruded tube. The wall was reinforced with elastic fiber to prevent dilation. The compliance of the vascular graft measured with the method of Hayashi et al. ranged from 0.2 to 0.3% mmHg -1. The initial Young's modulus was close to that of canine carotic artery, to which the porous polyurethane graft 4-cm long was anastomosed. Vascular grafts were occluded within 2 weeks after implantation, when their pore size was 0, 1.7, or 4.4 mum, whereas those with the pore size of 5.5, 7.4, and 30 mum were patent for longer than 4 weeks. When the vascular graft with the pore size of 30 mum was implanted for 6 months, the luminal surface was covered with neointima, but the endothelium-like cells appearing in the middle of the intima of the vascular graft were immature and sometimes had a very big nucleus. In addition, spindle-shaped, modified smooth muscle cells were noticed in the deep layer of the neointima, especially in the tissue where anastomotic intimal hyperplasia occurred.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalJournal of applied biomaterials : an official journal of the Society for Biomaterials
Volume4
Issue number4
Publication statusPublished - 1993 Dec
Externally publishedYes

Fingerprint

Polyurethanes
Grafts
Blood Vessels
Transplants
Tunica Intima
Pore size
Neointima
Stupor
Elastic Tissue
Elastic Modulus
Urethane
Ether
Compliance
Smooth Muscle Myocytes
Endothelium
Hyperplasia
Extrusion
Muscle
Canidae
Dilatation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fujimoto, K., Minato, M., Miyamoto, S., Kaneko, T., Kikuchi, H., Sakai, K., ... Ikada, Y. (1993). Porous polyurethane tubes as vascular graft. Journal of applied biomaterials : an official journal of the Society for Biomaterials, 4(4), 347-354.

Porous polyurethane tubes as vascular graft. / Fujimoto, Keiji; Minato, M.; Miyamoto, S.; Kaneko, T.; Kikuchi, H.; Sakai, K.; Okada, M.; Ikada, Y.

In: Journal of applied biomaterials : an official journal of the Society for Biomaterials, Vol. 4, No. 4, 12.1993, p. 347-354.

Research output: Contribution to journalArticle

Fujimoto, K, Minato, M, Miyamoto, S, Kaneko, T, Kikuchi, H, Sakai, K, Okada, M & Ikada, Y 1993, 'Porous polyurethane tubes as vascular graft.', Journal of applied biomaterials : an official journal of the Society for Biomaterials, vol. 4, no. 4, pp. 347-354.
Fujimoto, Keiji ; Minato, M. ; Miyamoto, S. ; Kaneko, T. ; Kikuchi, H. ; Sakai, K. ; Okada, M. ; Ikada, Y. / Porous polyurethane tubes as vascular graft. In: Journal of applied biomaterials : an official journal of the Society for Biomaterials. 1993 ; Vol. 4, No. 4. pp. 347-354.
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