Porous surface structure fabricated by breath figures that suppresses pseudomonas aeruginosa biofilm formation

Kengo Manabe, Shingo Nishizawa, Seimei Shiratori

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

As colonizers of medical-device surfaces, Pseudomonas aeruginosa strains present a serious source of infection and are of major concern. In this study, we fabricated films with porous surfaces by breath figures that disturb mergence by bacterial attachment, thereby impeding biofilm development. Previous studies have shown that microtopography prevents the development of P. aeruginosa biofilms. Accordingly we indented surfaces with patterns of micrometer-sized pores using breath figures at ordinary temperatures and pressures. The antimicrobial effect of surface figures was experimentally investigated by controlling the surface structure. The results suggested that pores of 5-11 μm in diameter effectively inhibit bacterial activity. It appears that biofilm development is precluded by the decreased contact area between the films and bacteria.

Original languageEnglish
Pages (from-to)11900-11905
Number of pages6
JournalACS Applied Materials and Interfaces
Volume5
Issue number22
DOIs
Publication statusPublished - 2013 Nov 27

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Biofilms
Surface structure
Pseudomonas aeruginosa
Bacteria
Pressure
Equipment and Supplies
Temperature
Infection

Keywords

  • antibacterial
  • biofilms
  • breath figures
  • microtopography
  • self-organization
  • surface structure

ASJC Scopus subject areas

  • Materials Science(all)
  • Medicine(all)

Cite this

Porous surface structure fabricated by breath figures that suppresses pseudomonas aeruginosa biofilm formation. / Manabe, Kengo; Nishizawa, Shingo; Shiratori, Seimei.

In: ACS Applied Materials and Interfaces, Vol. 5, No. 22, 27.11.2013, p. 11900-11905.

Research output: Contribution to journalArticle

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