Portal hypertension after successful hepatic portoenterostomy in biliary atresia

M. Saeki, T. Honna, M. Nakano, Tatsuo Kuroda

Research output: Contribution to journalArticle

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Abstract

Sixty percent of 139 patients with biliary atresia who underwent hepatic portoenterostomy (Kasai operation) from 1965 to 1994 became jaundice-free after the operation. Portal hypertension, which was confirmed by endoscopic observation of esophageal varices and/or thrombocytopenia (less than 100 x 10(3)/mm3), developed in 50% of unicteric long-term survivors. Esophageal varix was found initially between 11 months and 5 years of age in more than 70% of these portal hypertensive patients. On the contrary, thrombocytopenia developed at 6 years or older age in 63% of the patients. The incidence of portal hypertension was significantly lower in the patients whose serum bilirubin decreased less than 2mg/dl at 3 months after surgery than in the patients whose bilirubin stayed over 2mg/dl at the same postoperative time. Furthermore, re-do operation related significantly to the incidence of portal hypertension in jaundice-disappeared patients. Prophylactic endoscopic injection sclerotherapy and/or variceal ligation were sufficiently effective in the management of esophageal varices. Partial splenic embolization as well as splenectomy seems to be a treatment of choice for hypersplenism.

Original languageEnglish
Pages (from-to)648-652
Number of pages5
JournalNippon Geka Gakkai zasshi
Volume97
Issue number8
Publication statusPublished - 1996 Aug
Externally publishedYes

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Hepatic Portoenterostomy
Biliary Atresia
Portal Hypertension
Esophageal and Gastric Varices
Jaundice
Bilirubin
Thrombocytopenia
Hypersplenism
Sclerotherapy
Incidence
Splenectomy
Ligation
Survivors
Observation
Injections

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Portal hypertension after successful hepatic portoenterostomy in biliary atresia. / Saeki, M.; Honna, T.; Nakano, M.; Kuroda, Tatsuo.

In: Nippon Geka Gakkai zasshi, Vol. 97, No. 8, 08.1996, p. 648-652.

Research output: Contribution to journalArticle

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