Positive association of plasma homocysteine levels with cardio-ankle vascular index in a prospective study of japanese men from the general population

Eva Mariane Mantjoro, Kousuke Toyota, Hiroaki Kanouchi, Motahare Kheradmand, Hideshi Niimura, Kazuyo Kuwabara, Noriko Nakahata, Shin Ogawa, Keiichi Shimatani, Tara Sefanya Kairupan, Yora Nindita, Rie Ibusuki, Yasuhito Nerome, Tetsuhiro Owaki, Shigeho Maenohara, Toshiro Takezaki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: Observational studies have reported that elevated homocysteine (Hcy) levels are associated with the risk of cardiovascular disease (CVD). However, interventions that lower Hcy do not provide a corresponding risk reduction. Therefore, the causal role of Hcy in CVD remains unclear. This 5-year prospective study investigated the associations of Hcy levels, folate intake, and host factors with arterial stiffness among the general Japanese population. Methods: We prospectively recruited 658 participants (40–69 years old) from the general population during regular health checkup examinations. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) at baseline and the 5-year follow-up. Folate intake was estimated using a structured questionnaire. Genotyping was used to evaluate the MTHFR C677T and MS A2756G gene polymorphisms. Ultrafast liquid chromatography was used to measure total plasma Hcy levels. Association between these variables and CAVI values was evaluated using general linear regression and logistic regression models that were adjusted for atherosclerosis-related factors. Results: Men had higher Hcy levels and CAVI values and lower folate intake than women (all, p< 0.001). At baseline, Hcy, folate intake, and the two genotypes were not associated with CAVI values for both sexes. Among men, Hcy levels were positively associated with CAVI values at the 5-year follow-up (p=0.033). Folate intake and the two genotypes were not associated with the 5-year CAVI values. Conclusion: Plasma Hcy may be involved in arterial stiffness progression, as monitored using CAVI, among men.

Original languageEnglish
Pages (from-to)681-691
Number of pages11
JournalJournal of atherosclerosis and thrombosis
Volume23
Issue number6
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Arterial stiffness
  • Cardio-ankle vascular index
  • Gene polymorphism
  • Homocysteine

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

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  • Cite this

    Mantjoro, E. M., Toyota, K., Kanouchi, H., Kheradmand, M., Niimura, H., Kuwabara, K., Nakahata, N., Ogawa, S., Shimatani, K., Kairupan, T. S., Nindita, Y., Ibusuki, R., Nerome, Y., Owaki, T., Maenohara, S., & Takezaki, T. (2016). Positive association of plasma homocysteine levels with cardio-ankle vascular index in a prospective study of japanese men from the general population. Journal of atherosclerosis and thrombosis, 23(6), 681-691. https://doi.org/10.5551/jat.32243