Positron emission tomography for preoperative staging in patients with locally advanced or metastatic colorectal adenocarcinoma in lymph node metastasis

Chihiro Kosugi, Norio Saito, Koji Murakami, Atsushi Ochiai, Keiji Koda, Masato Ono, Masanori Sugito, Masaaki Ito, Kenji Oda, Kazuhiro Seike, Masaru Miyazaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background/Aims: The impact of positron emission tomography was prospectively evaluated using 18 (F)-fluoro-deoxyglucose (FDG-PET) for the detection of lymph node (LN) metastasis in preoperative locally advanced colorectal adenocarcinoma, compared with computed tomography (CT) and pathologic findings. Methodology: Fifty-three patients who were suspected of LN involvement by CT were staged preoperatively for LN metastasis using FDG-PET and CT. Regional LNs were classified into 3 groups, N1, N2-3, and N4, according to the Japanese General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus (6th Edition). A comparison of pathologic findings with CT and FDG-PET findings was used to calculate sensitivity, specificity, and accuracy. Results: The sensitivity, specificity and accuracy of CT/FDG-PET were 91.3%/52.2%, 91.7%/75.0% and 65.9%/72.3%, respectively, for N1, 91.7%/75.0%, 72.2%/94.4% and 77.1%/89.6%, respectively, for N2-3, and 100%/100%, 17.6%/100% and 41.7%/100%, respectively, for N4. The detection rate of the number of metastatic N1 LNs by CT was significantly higher than by FDG-PET, and not significantly in the N2-4 area. LNs hidden by strong halation of the primary tumor were not detected by FDG-PET. Conclusions: While FDG-PET is markedly more sensitive than CT for detection of N4 LN involvement, the number of metastatic LNs is difficult to determine.

Original languageEnglish
Pages (from-to)398-402
Number of pages5
JournalHepato-gastroenterology
Volume55
Issue number82-83
Publication statusPublished - 2008 Mar 1

Keywords

  • Colorectal carcinoma
  • Lymph node metastasis
  • Positron emission tomography

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Kosugi, C., Saito, N., Murakami, K., Ochiai, A., Koda, K., Ono, M., Sugito, M., Ito, M., Oda, K., Seike, K., & Miyazaki, M. (2008). Positron emission tomography for preoperative staging in patients with locally advanced or metastatic colorectal adenocarcinoma in lymph node metastasis. Hepato-gastroenterology, 55(82-83), 398-402.