Positron emission tomography for preoperative staging in patients with locally advanced or metastatic colorectal adenocarcinoma in lymph node metastasis

Chihiro Kosugi, Norio Saito, Koji Murakami, Atsushi Ochiai, Keiji Koda, Masato Ono, Masanori Sugito, Masaaki Ito, Kenji Oda, Kazuhiro Seike, Masaru Miyazaki

Research output: Contribution to journalArticle

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Abstract

Background/Aims: The impact of positron emission tomography was prospectively evaluated using 18 (F)-fluoro-deoxyglucose (FDG-PET) for the detection of lymph node (LN) metastasis in preoperative locally advanced colorectal adenocarcinoma, compared with computed tomography (CT) and pathologic findings. Methodology: Fifty-three patients who were suspected of LN involvement by CT were staged preoperatively for LN metastasis using FDG-PET and CT. Regional LNs were classified into 3 groups, N1, N2-3, and N4, according to the Japanese General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus (6th Edition). A comparison of pathologic findings with CT and FDG-PET findings was used to calculate sensitivity, specificity, and accuracy. Results: The sensitivity, specificity and accuracy of CT/FDG-PET were 91.3%/52.2%, 91.7%/75.0% and 65.9%/72.3%, respectively, for N1, 91.7%/75.0%, 72.2%/94.4% and 77.1%/89.6%, respectively, for N2-3, and 100%/100%, 17.6%/100% and 41.7%/100%, respectively, for N4. The detection rate of the number of metastatic N1 LNs by CT was significantly higher than by FDG-PET, and not significantly in the N2-4 area. LNs hidden by strong halation of the primary tumor were not detected by FDG-PET. Conclusions: While FDG-PET is markedly more sensitive than CT for detection of N4 LN involvement, the number of metastatic LNs is difficult to determine.

Original languageEnglish
Pages (from-to)398-402
Number of pages5
JournalHepato-Gastroenterology
Volume55
Issue number82-83
Publication statusPublished - 2008 Mar
Externally publishedYes

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Positron-Emission Tomography
Adenocarcinoma
Lymph Nodes
Tomography
Neoplasm Metastasis
Anus Neoplasms
Sensitivity and Specificity
Deoxyglucose
Rectal Neoplasms
Colonic Neoplasms
Neoplasms

Keywords

  • Colorectal carcinoma
  • Lymph node metastasis
  • Positron emission tomography

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kosugi, C., Saito, N., Murakami, K., Ochiai, A., Koda, K., Ono, M., ... Miyazaki, M. (2008). Positron emission tomography for preoperative staging in patients with locally advanced or metastatic colorectal adenocarcinoma in lymph node metastasis. Hepato-Gastroenterology, 55(82-83), 398-402.

Positron emission tomography for preoperative staging in patients with locally advanced or metastatic colorectal adenocarcinoma in lymph node metastasis. / Kosugi, Chihiro; Saito, Norio; Murakami, Koji; Ochiai, Atsushi; Koda, Keiji; Ono, Masato; Sugito, Masanori; Ito, Masaaki; Oda, Kenji; Seike, Kazuhiro; Miyazaki, Masaru.

In: Hepato-Gastroenterology, Vol. 55, No. 82-83, 03.2008, p. 398-402.

Research output: Contribution to journalArticle

Kosugi, C, Saito, N, Murakami, K, Ochiai, A, Koda, K, Ono, M, Sugito, M, Ito, M, Oda, K, Seike, K & Miyazaki, M 2008, 'Positron emission tomography for preoperative staging in patients with locally advanced or metastatic colorectal adenocarcinoma in lymph node metastasis', Hepato-Gastroenterology, vol. 55, no. 82-83, pp. 398-402.
Kosugi, Chihiro ; Saito, Norio ; Murakami, Koji ; Ochiai, Atsushi ; Koda, Keiji ; Ono, Masato ; Sugito, Masanori ; Ito, Masaaki ; Oda, Kenji ; Seike, Kazuhiro ; Miyazaki, Masaru. / Positron emission tomography for preoperative staging in patients with locally advanced or metastatic colorectal adenocarcinoma in lymph node metastasis. In: Hepato-Gastroenterology. 2008 ; Vol. 55, No. 82-83. pp. 398-402.
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abstract = "Background/Aims: The impact of positron emission tomography was prospectively evaluated using 18 (F)-fluoro-deoxyglucose (FDG-PET) for the detection of lymph node (LN) metastasis in preoperative locally advanced colorectal adenocarcinoma, compared with computed tomography (CT) and pathologic findings. Methodology: Fifty-three patients who were suspected of LN involvement by CT were staged preoperatively for LN metastasis using FDG-PET and CT. Regional LNs were classified into 3 groups, N1, N2-3, and N4, according to the Japanese General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus (6th Edition). A comparison of pathologic findings with CT and FDG-PET findings was used to calculate sensitivity, specificity, and accuracy. Results: The sensitivity, specificity and accuracy of CT/FDG-PET were 91.3{\%}/52.2{\%}, 91.7{\%}/75.0{\%} and 65.9{\%}/72.3{\%}, respectively, for N1, 91.7{\%}/75.0{\%}, 72.2{\%}/94.4{\%} and 77.1{\%}/89.6{\%}, respectively, for N2-3, and 100{\%}/100{\%}, 17.6{\%}/100{\%} and 41.7{\%}/100{\%}, respectively, for N4. The detection rate of the number of metastatic N1 LNs by CT was significantly higher than by FDG-PET, and not significantly in the N2-4 area. LNs hidden by strong halation of the primary tumor were not detected by FDG-PET. Conclusions: While FDG-PET is markedly more sensitive than CT for detection of N4 LN involvement, the number of metastatic LNs is difficult to determine.",
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T1 - Positron emission tomography for preoperative staging in patients with locally advanced or metastatic colorectal adenocarcinoma in lymph node metastasis

AU - Kosugi, Chihiro

AU - Saito, Norio

AU - Murakami, Koji

AU - Ochiai, Atsushi

AU - Koda, Keiji

AU - Ono, Masato

AU - Sugito, Masanori

AU - Ito, Masaaki

AU - Oda, Kenji

AU - Seike, Kazuhiro

AU - Miyazaki, Masaru

PY - 2008/3

Y1 - 2008/3

N2 - Background/Aims: The impact of positron emission tomography was prospectively evaluated using 18 (F)-fluoro-deoxyglucose (FDG-PET) for the detection of lymph node (LN) metastasis in preoperative locally advanced colorectal adenocarcinoma, compared with computed tomography (CT) and pathologic findings. Methodology: Fifty-three patients who were suspected of LN involvement by CT were staged preoperatively for LN metastasis using FDG-PET and CT. Regional LNs were classified into 3 groups, N1, N2-3, and N4, according to the Japanese General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus (6th Edition). A comparison of pathologic findings with CT and FDG-PET findings was used to calculate sensitivity, specificity, and accuracy. Results: The sensitivity, specificity and accuracy of CT/FDG-PET were 91.3%/52.2%, 91.7%/75.0% and 65.9%/72.3%, respectively, for N1, 91.7%/75.0%, 72.2%/94.4% and 77.1%/89.6%, respectively, for N2-3, and 100%/100%, 17.6%/100% and 41.7%/100%, respectively, for N4. The detection rate of the number of metastatic N1 LNs by CT was significantly higher than by FDG-PET, and not significantly in the N2-4 area. LNs hidden by strong halation of the primary tumor were not detected by FDG-PET. Conclusions: While FDG-PET is markedly more sensitive than CT for detection of N4 LN involvement, the number of metastatic LNs is difficult to determine.

AB - Background/Aims: The impact of positron emission tomography was prospectively evaluated using 18 (F)-fluoro-deoxyglucose (FDG-PET) for the detection of lymph node (LN) metastasis in preoperative locally advanced colorectal adenocarcinoma, compared with computed tomography (CT) and pathologic findings. Methodology: Fifty-three patients who were suspected of LN involvement by CT were staged preoperatively for LN metastasis using FDG-PET and CT. Regional LNs were classified into 3 groups, N1, N2-3, and N4, according to the Japanese General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus (6th Edition). A comparison of pathologic findings with CT and FDG-PET findings was used to calculate sensitivity, specificity, and accuracy. Results: The sensitivity, specificity and accuracy of CT/FDG-PET were 91.3%/52.2%, 91.7%/75.0% and 65.9%/72.3%, respectively, for N1, 91.7%/75.0%, 72.2%/94.4% and 77.1%/89.6%, respectively, for N2-3, and 100%/100%, 17.6%/100% and 41.7%/100%, respectively, for N4. The detection rate of the number of metastatic N1 LNs by CT was significantly higher than by FDG-PET, and not significantly in the N2-4 area. LNs hidden by strong halation of the primary tumor were not detected by FDG-PET. Conclusions: While FDG-PET is markedly more sensitive than CT for detection of N4 LN involvement, the number of metastatic LNs is difficult to determine.

KW - Colorectal carcinoma

KW - Lymph node metastasis

KW - Positron emission tomography

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