Possibility of lung cancer risk in indium-exposed workers

An 11-year multicenter cohort study

Makiko Nakano, Kazuyuki Omae, Akiyo Tanaka, Miyuki Hirata

Research output: Contribution to journalArticle

Abstract

Background: We established a causal relationship between indium exposure and lung interstitial and emphysematous effects. Lung cancer has been clearly demonstrated in rats and mice exposed to indium phosphide and in rats exposed to indium tin oxide. However, no information is available on human indium-related lung cancer. Methods: The baseline studies were conducted on 381 indium-exposed and 150 referent workers in 11 factories from 2003 to 2006. Items examined included indium concentration in serum (In-S), occupational history, Krebs von den Lungen-6 (KL-6), chest high-resolution computed tomography (HRCT), medical history, smoking habits, and subjective symptoms. Subjects received follow-up health checkups, and a total of 220 indium-exposed and 26 nonexposed workers were examined at least once with chest HRCT from 2013 to 2018. Results: Four lung cancer cases were identified only in indium-exposed workers. Two were prevalent cases and two were incident cases. The averages (range) of age (years), exposure duration (years), In-S (μg/L), and KL-6 (U/mL) at the baseline survey were 58 (50-74), 1.7 (0.3-4.8), 3.1 (0.3-9.7), and 663 (414-942). The mean (range) latency from initial indium exposure was 5.3 (0.4-11) years. The HRCT findings in two incident cases were mild interstitial/emphysematous change and mild interstitial change. The standardized incidence ratio (SIR) of the incident cases was 1.89 (95%CI 0.52-6.88). Conclusions: Although the SIR was not statistically significant, there was an undeniable possibility of indium-related lung cancer due to the short follow-up duration being insufficient to disclose lung cancer and the small number of lung cancer cases. Further follow-up is necessary.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalJournal of occupational health
Volume61
Issue number3
DOIs
Publication statusPublished - 2019 May 1

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Indium
Multicenter Studies
Lung Neoplasms
Cohort Studies
Tomography
Rats
Thorax
Incidence
Habits
Industrial plants
Smoking
Health
Lung
Serum

Keywords

  • Cohort study
  • Human
  • Indium
  • ITO
  • Lung cancer

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Possibility of lung cancer risk in indium-exposed workers : An 11-year multicenter cohort study. / Nakano, Makiko; Omae, Kazuyuki; Tanaka, Akiyo; Hirata, Miyuki.

In: Journal of occupational health, Vol. 61, No. 3, 01.05.2019, p. 251-256.

Research output: Contribution to journalArticle

Nakano, Makiko ; Omae, Kazuyuki ; Tanaka, Akiyo ; Hirata, Miyuki. / Possibility of lung cancer risk in indium-exposed workers : An 11-year multicenter cohort study. In: Journal of occupational health. 2019 ; Vol. 61, No. 3. pp. 251-256.
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