Possible Association between Obesity and Posttransplantation Complications Including Infectious Diseases and Acute Graft-versus-Host Disease

Shigeo Fuji, Sung Won Kim, Ken ichi Yoshimura, Hideki Akiyama, Shinichiro Okamoto, Hiroshi Sao, Junko Takita, Naoki Kobayashi, Shin ichiro Mori

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Both obesity and malnutrition are considered risk factors for complications after bone marrow transplantation (BMT). To elucidate the impact of pretransplantation body mass index (BMI) on clinical outcome, we performed a retrospective cohort study with registration data from the Japan Marrow Donor Program (JMDP). Between January 1998 and December 2005, a total of 3935 patients received unrelated BMT through the JMDP; of these, 3827 patients for whom pretransplantation height and weight data were available were included in the study. Patients were stratified according to pretransplantation BMI values (low BMI: BMI < 18 kg/m2, n = 295; normal BMI: 18 ≤ BMI < 25 kg/m2, n = 2906; overweight: 25 ≤ BMI <30 kg/m2, n = 565; obese: 30 kg/m2 ≤ BMI, n = 61). In a univariate analysis, pretransplantation BMI was associated with a significantly greater risk of grade II-IV acute graft-versus-host disease (GVHD; P = .03). Multivariate analysis showed that pretransplantation BMI tended to be associated with an increased risk of grade II-IV acute GVHD (P = .07). Obesity was associated with an increased risk of infection compared with normal BMI (odds ratio = 1.9; 95% confidence interval = 1.1 to 3.2; P = .02). Our findings demonstrate a correlation between pretransplantation BMI and posttransplantation complications. Although BMI depends strongly on multiple factors, the effect of obesity on clinical outcome should be evaluated in a prospective study.

Original languageEnglish
Pages (from-to)73-82
Number of pages10
JournalBiology of Blood and Marrow Transplantation
Volume15
Issue number1
DOIs
Publication statusPublished - 2009 Jan

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Graft vs Host Disease
Communicable Diseases
Body Mass Index
Obesity
Bone Marrow Transplantation
Japan
Bone Marrow
Tissue Donors
Malnutrition
Cohort Studies
Multivariate Analysis
Retrospective Studies
Odds Ratio
Prospective Studies
Confidence Intervals

Keywords

  • Acute graft-versus-host disease
  • Allogeneic transplantation
  • Infection
  • Obesity

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this

Possible Association between Obesity and Posttransplantation Complications Including Infectious Diseases and Acute Graft-versus-Host Disease. / Fuji, Shigeo; Kim, Sung Won; Yoshimura, Ken ichi; Akiyama, Hideki; Okamoto, Shinichiro; Sao, Hiroshi; Takita, Junko; Kobayashi, Naoki; Mori, Shin ichiro.

In: Biology of Blood and Marrow Transplantation, Vol. 15, No. 1, 01.2009, p. 73-82.

Research output: Contribution to journalArticle

Fuji, Shigeo ; Kim, Sung Won ; Yoshimura, Ken ichi ; Akiyama, Hideki ; Okamoto, Shinichiro ; Sao, Hiroshi ; Takita, Junko ; Kobayashi, Naoki ; Mori, Shin ichiro. / Possible Association between Obesity and Posttransplantation Complications Including Infectious Diseases and Acute Graft-versus-Host Disease. In: Biology of Blood and Marrow Transplantation. 2009 ; Vol. 15, No. 1. pp. 73-82.
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