Possible association between subtypes of dry eye disease and seasonal variation

Masahiko Ayaki, Motoko Kawashima, Miki Uchino, Kazuo Tsubota, Kazuno Negishi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). Methods: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups. Main outcome measures were differences in the severity of the signs and symptoms of DED between the most and least severe seasons. Results: The majority of DED symptoms were most severe during spring and least severe in summer. Significant differences between these two seasons were found for irritation (P=0.001), pain (P=0.007), blurring (P=0.000), and photophobia (P=0.007) in the DED group. Superficial punctate keratopathy (P=0.001) and tear break-up time (BUT; P=0.000) results also indicated that DED was most severe in spring. In contrast, fewer patients had low Schirmer test results in spring, although this was not statistically significant (P=0.061). Conclusion: Our results demonstrated that the severity of DED is seasonal, which may explain the increase of short BUT-type DED cases observed in spring when air pollen counts are highest.

Original languageEnglish
Pages (from-to)1769-1775
Number of pages7
JournalClinical Ophthalmology
Volume11
DOIs
Publication statusPublished - 2017 Sep 30

Fingerprint

Eye Diseases
Signs and Symptoms
Photophobia
Pollen
Tears
Case-Control Studies
Japan
Air
Outcome Assessment (Health Care)
Pain

Keywords

  • Air pollen
  • Allergic conjunctivitis
  • Cornea
  • Dry eye disease
  • Hay fever
  • Ocular surface
  • Seasonality
  • Tear break-up time
  • Tear production

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Possible association between subtypes of dry eye disease and seasonal variation. / Ayaki, Masahiko; Kawashima, Motoko; Uchino, Miki; Tsubota, Kazuo; Negishi, Kazuno.

In: Clinical Ophthalmology, Vol. 11, 30.09.2017, p. 1769-1775.

Research output: Contribution to journalArticle

Ayaki, Masahiko ; Kawashima, Motoko ; Uchino, Miki ; Tsubota, Kazuo ; Negishi, Kazuno. / Possible association between subtypes of dry eye disease and seasonal variation. In: Clinical Ophthalmology. 2017 ; Vol. 11. pp. 1769-1775.
@article{5bfd37b734e64a149a0346181dc16185,
title = "Possible association between subtypes of dry eye disease and seasonal variation",
abstract = "Purpose: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). Methods: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups. Main outcome measures were differences in the severity of the signs and symptoms of DED between the most and least severe seasons. Results: The majority of DED symptoms were most severe during spring and least severe in summer. Significant differences between these two seasons were found for irritation (P=0.001), pain (P=0.007), blurring (P=0.000), and photophobia (P=0.007) in the DED group. Superficial punctate keratopathy (P=0.001) and tear break-up time (BUT; P=0.000) results also indicated that DED was most severe in spring. In contrast, fewer patients had low Schirmer test results in spring, although this was not statistically significant (P=0.061). Conclusion: Our results demonstrated that the severity of DED is seasonal, which may explain the increase of short BUT-type DED cases observed in spring when air pollen counts are highest.",
keywords = "Air pollen, Allergic conjunctivitis, Cornea, Dry eye disease, Hay fever, Ocular surface, Seasonality, Tear break-up time, Tear production",
author = "Masahiko Ayaki and Motoko Kawashima and Miki Uchino and Kazuo Tsubota and Kazuno Negishi",
year = "2017",
month = "9",
day = "30",
doi = "10.2147/OPTH.S148650",
language = "English",
volume = "11",
pages = "1769--1775",
journal = "Clinical Ophthalmology",
issn = "1177-5467",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Possible association between subtypes of dry eye disease and seasonal variation

AU - Ayaki, Masahiko

AU - Kawashima, Motoko

AU - Uchino, Miki

AU - Tsubota, Kazuo

AU - Negishi, Kazuno

PY - 2017/9/30

Y1 - 2017/9/30

N2 - Purpose: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). Methods: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups. Main outcome measures were differences in the severity of the signs and symptoms of DED between the most and least severe seasons. Results: The majority of DED symptoms were most severe during spring and least severe in summer. Significant differences between these two seasons were found for irritation (P=0.001), pain (P=0.007), blurring (P=0.000), and photophobia (P=0.007) in the DED group. Superficial punctate keratopathy (P=0.001) and tear break-up time (BUT; P=0.000) results also indicated that DED was most severe in spring. In contrast, fewer patients had low Schirmer test results in spring, although this was not statistically significant (P=0.061). Conclusion: Our results demonstrated that the severity of DED is seasonal, which may explain the increase of short BUT-type DED cases observed in spring when air pollen counts are highest.

AB - Purpose: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). Methods: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups. Main outcome measures were differences in the severity of the signs and symptoms of DED between the most and least severe seasons. Results: The majority of DED symptoms were most severe during spring and least severe in summer. Significant differences between these two seasons were found for irritation (P=0.001), pain (P=0.007), blurring (P=0.000), and photophobia (P=0.007) in the DED group. Superficial punctate keratopathy (P=0.001) and tear break-up time (BUT; P=0.000) results also indicated that DED was most severe in spring. In contrast, fewer patients had low Schirmer test results in spring, although this was not statistically significant (P=0.061). Conclusion: Our results demonstrated that the severity of DED is seasonal, which may explain the increase of short BUT-type DED cases observed in spring when air pollen counts are highest.

KW - Air pollen

KW - Allergic conjunctivitis

KW - Cornea

KW - Dry eye disease

KW - Hay fever

KW - Ocular surface

KW - Seasonality

KW - Tear break-up time

KW - Tear production

UR - http://www.scopus.com/inward/record.url?scp=85032432313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032432313&partnerID=8YFLogxK

U2 - 10.2147/OPTH.S148650

DO - 10.2147/OPTH.S148650

M3 - Article

AN - SCOPUS:85032432313

VL - 11

SP - 1769

EP - 1775

JO - Clinical Ophthalmology

JF - Clinical Ophthalmology

SN - 1177-5467

ER -