Abstract
We present a case of purpura associated with concomitant ingestion of cilostazol, aspirin and grapefruit juice. A 79-year-old man with atherosclerosis obliterans, taking cilostazol and aspirin, complained of purpura. Interview by a pharmacist revealed that he had been taking grapefruit juice for a month. His purpura disappeared upon cessation of grapefruit juice, although his medication was not altered. The most probable cause of his purpura is an increase in the blood level of cilostazol because of the inhibition of cilostazol metabolism by components of grapefruit juice. Aspirin may possibly have potentiated the risk of purpura. Grapefruit juice should be avoided in patients taking cilostazol, especially in patients being concomitantly treated with other anticoagulants.
| Original language | English |
|---|---|
| Pages (from-to) | 457-459 |
| Number of pages | 3 |
| Journal | Journal of Clinical Pharmacy and Therapeutics |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2007 Oct |
| Externally published | Yes |
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Keywords
- Aspirin
- Cilostazol
- Grapefruit
- Purpura
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice. / Taniguchi, K.; Ohtani, Hisakazu; Ikemoto, T.; Miki, A.; Hori, Satoko; Sawada, Y.
In: Journal of Clinical Pharmacy and Therapeutics, Vol. 32, No. 5, 10.2007, p. 457-459.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice
AU - Taniguchi, K.
AU - Ohtani, Hisakazu
AU - Ikemoto, T.
AU - Miki, A.
AU - Hori, Satoko
AU - Sawada, Y.
PY - 2007/10
Y1 - 2007/10
N2 - We present a case of purpura associated with concomitant ingestion of cilostazol, aspirin and grapefruit juice. A 79-year-old man with atherosclerosis obliterans, taking cilostazol and aspirin, complained of purpura. Interview by a pharmacist revealed that he had been taking grapefruit juice for a month. His purpura disappeared upon cessation of grapefruit juice, although his medication was not altered. The most probable cause of his purpura is an increase in the blood level of cilostazol because of the inhibition of cilostazol metabolism by components of grapefruit juice. Aspirin may possibly have potentiated the risk of purpura. Grapefruit juice should be avoided in patients taking cilostazol, especially in patients being concomitantly treated with other anticoagulants.
AB - We present a case of purpura associated with concomitant ingestion of cilostazol, aspirin and grapefruit juice. A 79-year-old man with atherosclerosis obliterans, taking cilostazol and aspirin, complained of purpura. Interview by a pharmacist revealed that he had been taking grapefruit juice for a month. His purpura disappeared upon cessation of grapefruit juice, although his medication was not altered. The most probable cause of his purpura is an increase in the blood level of cilostazol because of the inhibition of cilostazol metabolism by components of grapefruit juice. Aspirin may possibly have potentiated the risk of purpura. Grapefruit juice should be avoided in patients taking cilostazol, especially in patients being concomitantly treated with other anticoagulants.
KW - Aspirin
KW - Cilostazol
KW - Grapefruit
KW - Purpura
UR - http://www.scopus.com/inward/record.url?scp=34548644986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548644986&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2710.2007.00844.x
DO - 10.1111/j.1365-2710.2007.00844.x
M3 - Article
C2 - 17875111
AN - SCOPUS:34548644986
VL - 32
SP - 457
EP - 459
JO - Journal of Clinical Pharmacy and Therapeutics
JF - Journal of Clinical Pharmacy and Therapeutics
SN - 0269-4727
IS - 5
ER -