Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice

K. Taniguchi, H. Ohtani, T. Ikemoto, A. Miki, S. Hori, Y. Sawada

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

We present a case of purpura associated with concomitant ingestion of cilostazol, aspirin and grapefruit juice. A 79-year-old man with atherosclerosis obliterans, taking cilostazol and aspirin, complained of purpura. Interview by a pharmacist revealed that he had been taking grapefruit juice for a month. His purpura disappeared upon cessation of grapefruit juice, although his medication was not altered. The most probable cause of his purpura is an increase in the blood level of cilostazol because of the inhibition of cilostazol metabolism by components of grapefruit juice. Aspirin may possibly have potentiated the risk of purpura. Grapefruit juice should be avoided in patients taking cilostazol, especially in patients being concomitantly treated with other anticoagulants.

Original languageEnglish
Pages (from-to)457-459
Number of pages3
JournalJournal of Clinical Pharmacy and Therapeutics
Volume32
Issue number5
DOIs
Publication statusPublished - 2007 Oct 1
Externally publishedYes

Keywords

  • Aspirin
  • Cilostazol
  • Grapefruit
  • Purpura

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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