Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to α-interferon in chronic myelogenous leukemia

Tokiko Inoue, Arinobu Tojo, Daisuke Tsuchimoto, Shin Ichiro Okamoto, Hiromi Ogura, Kenzaburo Tani, Keiya Ozawa, Masabumi Shibuya, Shigetaka Asano

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Abstract

Twenty six patients with Philadelphia chromosome (Ph1) positive chronic myelogenous leukemia (CML) treated with IFN-α were classified on the basis of the fusion pattern of BCR/ABL chimeric mRNA determined by a reverse-transcriptase-polymerase chain reaction (RT-PCR) method. The relationship between the fusion pattern of BCR/ABL mRNA and the clinical outcome was also analysed. Twelve patients showed M-bcr exon 3/ABL exon 2 (B3/A2) chimeric mRNA and nine had M-bcr exon 2/ABL exon 2 (B2/A2) mRNA. Eleven of the 12 patients with B3/A2 achieved complete hematological response with IFN-α therapy, as did three of the nine patients with B2/A2. The mean duration to blastic crisis was significantly longer in the B3/A2 patients (mean 52.4 months) than in the B2/A2 patients (mean 26.2 months) (p<0.01). These results suggest that the fusion pattern of BCR/ABL mRNA may affect the therapeutic response to IFN-α and clinical outcome in CML patients.

Original languageEnglish
Pages (from-to)948-951
Number of pages4
JournalLeukemia
Volume6
Issue number9
Publication statusPublished - 1992 Sep
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Inoue, T., Tojo, A., Tsuchimoto, D., Okamoto, S. I., Ogura, H., Tani, K., Ozawa, K., Shibuya, M., & Asano, S. (1992). Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to α-interferon in chronic myelogenous leukemia. Leukemia, 6(9), 948-951.