Possible importance of immunoglobulin e in foetal loss by mothers with anti-SSA antibody

I. Sekigawa, N. Seta, M. Yamada, N. Iida, H. Hashimoto, H. Ogawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: The incidence of foetal loss and/or adverse foetal outcomes, including congenital heart block (CHB), has been investigated in mothers with anti-SSA antibody detected by immunodiffusion or counter-immunoelectrophoresis methods. We investigated the relationship between several serum parameters (such as autoantibodies and immunoglobulins) and foetal loss in patients with anti-SSA antibody, measured by enzyme-linked immunosorbent assay (ELISA). Material and methods: Thirty-seven women who showed positivity for anti-SSA antibody and had a history of pregnancy were included in this study. Immunoglobulins and several autoantibodies were assayed by routine laboratory methods at our hospital. Results: Our data indicated that immunoglobulin E (IgE) levels were significantly higher in the anti-SSA antibody positive women with foetal loss than in those without, and that a strong positive correlation between IgE and anti-SSA antibody levels was observed in the former group, but not in the latter. Conclusion: The serum IgE level seems to be an important factor in the occurrence of foetal loss in mothers with anti-SSA antibody detected by ELISA.

Original languageEnglish
Pages (from-to)44-46
Number of pages3
JournalScandinavian Journal of Rheumatology
Volume33
Issue number1
DOIs
Publication statusPublished - 2004

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Immunoglobulins
Anti-Idiotypic Antibodies
Mothers
Immunoglobulin E
Autoantibodies
Enzyme-Linked Immunosorbent Assay
Reproductive History
Immunoelectrophoresis
Immunodiffusion
Serum
Incidence

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Possible importance of immunoglobulin e in foetal loss by mothers with anti-SSA antibody. / Sekigawa, I.; Seta, N.; Yamada, M.; Iida, N.; Hashimoto, H.; Ogawa, H.

In: Scandinavian Journal of Rheumatology, Vol. 33, No. 1, 2004, p. 44-46.

Research output: Contribution to journalArticle

Sekigawa, I. ; Seta, N. ; Yamada, M. ; Iida, N. ; Hashimoto, H. ; Ogawa, H. / Possible importance of immunoglobulin e in foetal loss by mothers with anti-SSA antibody. In: Scandinavian Journal of Rheumatology. 2004 ; Vol. 33, No. 1. pp. 44-46.
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