Possible involvement of central atrial natriuretic polypeptide in regulation of hypothalamo-pituitary-adrenal axis in conscious rats

Hiroshi Itoh, Kazuwa Nakao, Goro Katsuura, Narito Morii, Takayuki Yamada, Shozo Shiono, Makoto Sakamoto, Akira Sugawara, Yoshihiko Saito, Masami Eigyo, Akira Matsushita, Hiroo Imura

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The effects of intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and atrial natriuretic polypeptide (ANP) on the plasma corticosterone level were studied in conscious, unrestrained rats. Although i.c.v. injection of ANP had no apparent effect on the basal plasma corticosterone level, it attenuated the plasma corticosterone increase induced by centrally injected AII dose-dependently. These results suggest that ANP in the brain is involved in the regulation of the hypothalamo-pituitary-adrenal axis.

Original languageEnglish
Pages (from-to)254-258
Number of pages5
JournalNeuroscience Letters
Volume69
Issue number3
Publication statusPublished - 1986 Sep 12
Externally publishedYes

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Corticosterone
Angiotensin II
Peptides
Injections
Brain

Keywords

  • Angiotensin II
  • Atrial natriuretic polypeptide
  • Corticosterone
  • Hypothalamo-pituitary-adrenal axis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Possible involvement of central atrial natriuretic polypeptide in regulation of hypothalamo-pituitary-adrenal axis in conscious rats. / Itoh, Hiroshi; Nakao, Kazuwa; Katsuura, Goro; Morii, Narito; Yamada, Takayuki; Shiono, Shozo; Sakamoto, Makoto; Sugawara, Akira; Saito, Yoshihiko; Eigyo, Masami; Matsushita, Akira; Imura, Hiroo.

In: Neuroscience Letters, Vol. 69, No. 3, 12.09.1986, p. 254-258.

Research output: Contribution to journalArticle

Itoh, H, Nakao, K, Katsuura, G, Morii, N, Yamada, T, Shiono, S, Sakamoto, M, Sugawara, A, Saito, Y, Eigyo, M, Matsushita, A & Imura, H 1986, 'Possible involvement of central atrial natriuretic polypeptide in regulation of hypothalamo-pituitary-adrenal axis in conscious rats', Neuroscience Letters, vol. 69, no. 3, pp. 254-258.
Itoh, Hiroshi ; Nakao, Kazuwa ; Katsuura, Goro ; Morii, Narito ; Yamada, Takayuki ; Shiono, Shozo ; Sakamoto, Makoto ; Sugawara, Akira ; Saito, Yoshihiko ; Eigyo, Masami ; Matsushita, Akira ; Imura, Hiroo. / Possible involvement of central atrial natriuretic polypeptide in regulation of hypothalamo-pituitary-adrenal axis in conscious rats. In: Neuroscience Letters. 1986 ; Vol. 69, No. 3. pp. 254-258.
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