Possible Mechanisms of Vascular Relaxation Induced by Pulsed-UV Laser

Yuji Morimoto, Tsunenori Arai, Hirotaka Matsuo, Makoto Kikuchi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study was designed to examine the mechanism of vasorelaxation induced by pulsed-UV laser. Luminal diameters of rat femoral arteries were measured prior to and following krypton-fluoride excimer laser irradiation of 248 nm in wavelength. The diameter was enlarged to 1.3 times the preirradiated size at 1 or 10 Hz irradiation when the fluence was over 2.0 mJ/pulse/mm2, while the diameter reached 1.8 times at 100 Hz with a fluence of 0.8 mJ/pulse/mm2. Vasorelaxation by the 100 Hz irradiation was inhibited when the artery was pretreated with methylene blue but was enhanced with superoxide dismutase. Pathological analysis revealed an ablation crater and vacuole formation in the vessel at 1 or 10 Hz irradiation, but these changes were not remarkable in the 100 Hz-exposed sample. These findings suggest that vasorelaxation induced by the pulsed UV irradiation at 1 or 10 Hz results from structural alteration of vascular smooth muscle by the ablation crater or vacuolization. On the other hand, a possible mechanism of vasorelaxation at the 100 Hz irradiation is partially related to nitric oxide.

Original languageEnglish
Pages (from-to)388-393
Number of pages6
JournalPhotochemistry and Photobiology
Volume68
Issue number3
Publication statusPublished - 1998 Sep
Externally publishedYes

Fingerprint

ultraviolet lasers
Vasodilation
Blood Vessels
pulsed lasers
Lasers
Irradiation
irradiation
Pulse
Ablation
arteries
craters
Excimer Lasers
ablation
Methylene Blue
fluence
krypton fluoride lasers
Femoral Artery
Vacuoles
Vascular Smooth Muscle
Superoxide Dismutase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

Cite this

Morimoto, Y., Arai, T., Matsuo, H., & Kikuchi, M. (1998). Possible Mechanisms of Vascular Relaxation Induced by Pulsed-UV Laser. Photochemistry and Photobiology, 68(3), 388-393.

Possible Mechanisms of Vascular Relaxation Induced by Pulsed-UV Laser. / Morimoto, Yuji; Arai, Tsunenori; Matsuo, Hirotaka; Kikuchi, Makoto.

In: Photochemistry and Photobiology, Vol. 68, No. 3, 09.1998, p. 388-393.

Research output: Contribution to journalArticle

Morimoto, Y, Arai, T, Matsuo, H & Kikuchi, M 1998, 'Possible Mechanisms of Vascular Relaxation Induced by Pulsed-UV Laser', Photochemistry and Photobiology, vol. 68, no. 3, pp. 388-393.
Morimoto Y, Arai T, Matsuo H, Kikuchi M. Possible Mechanisms of Vascular Relaxation Induced by Pulsed-UV Laser. Photochemistry and Photobiology. 1998 Sep;68(3):388-393.
Morimoto, Yuji ; Arai, Tsunenori ; Matsuo, Hirotaka ; Kikuchi, Makoto. / Possible Mechanisms of Vascular Relaxation Induced by Pulsed-UV Laser. In: Photochemistry and Photobiology. 1998 ; Vol. 68, No. 3. pp. 388-393.
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