Possible postmortem serum markers for differentiation between fresh-, saltwater drowning and acute cardiac death

A preliminary investigation

Bao Li Zhu, Kaori Ishida, Mari Taniguchi, Li Quan, Shigeki Oritani, Kohei Tsuda, Yasunobu Kamikodai, Masaki Q Fujita, Hitoshi Maeda

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The aim of the present study was to investigate the differences in postmortem blood biochemistry between fresh-, saltwater drowning and acute myocardial infarction/ischemia (AMI) (n = 11, n = 15 and n = 23, respectively; postmortem interval <48 h). Left and right cardiac blood samples were examined for the serum markers: sodium (Na), chloride (Cl), magnesium (Mg), blood urea nitrogen (BUN), creatinine (Cr), pulmonary surfactant-associated protein A (SP-A) and cardiac troponin T (cTn-T). The most efficient markers were the left-right cardiac BUN ratio for determination of drowning (hemodilution) and the left heart blood Mg level for differentiation between fresh- and saltwater aspiration. A characteristics feature of saltwater drowning was a low left-right BUN ratio and a marked elevation in the serum Cl, Mg and Ca levels of the left heart blood. Serum cTn-T level was usually low in drowning, showing a difference from most cases of AMI. Freshwater drowning showed a significant elevation of serum SP-A, although there was considerable overlapping with saltwater drowning and AMI. These findings suggested the usefulness of serum markers in the investigation of death from drownings.

Original languageEnglish
JournalLegal Medicine
Volume5
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Biomarkers
Blood Urea Nitrogen
Myocardial Ischemia
Troponin T
Myocardial Infarction
Fresh Water
Magnesium
Serum
Pulmonary Surfactant-Associated Protein A
Hemodilution
Magnesium Chloride
Staphylococcal Protein A
Sodium Chloride
Surface-Active Agents
Biochemistry
Creatinine

Keywords

  • Blood biochemistry
  • Blood urea nitrogen
  • Cardiac troponin T
  • Creatinine
  • Drowning
  • Electrolyte
  • Forensic pathology
  • Mineral
  • Pulmonary surfactant-associated protein A

ASJC Scopus subject areas

  • Genetics
  • Pathology and Forensic Medicine
  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health

Cite this

Possible postmortem serum markers for differentiation between fresh-, saltwater drowning and acute cardiac death : A preliminary investigation. / Zhu, Bao Li; Ishida, Kaori; Taniguchi, Mari; Quan, Li; Oritani, Shigeki; Tsuda, Kohei; Kamikodai, Yasunobu; Fujita, Masaki Q; Maeda, Hitoshi.

In: Legal Medicine, Vol. 5, No. SUPPL. 1, 2003.

Research output: Contribution to journalArticle

Zhu, Bao Li ; Ishida, Kaori ; Taniguchi, Mari ; Quan, Li ; Oritani, Shigeki ; Tsuda, Kohei ; Kamikodai, Yasunobu ; Fujita, Masaki Q ; Maeda, Hitoshi. / Possible postmortem serum markers for differentiation between fresh-, saltwater drowning and acute cardiac death : A preliminary investigation. In: Legal Medicine. 2003 ; Vol. 5, No. SUPPL. 1.
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