Post-transplant lymphoproliferative disorder of the adrenal gland after allogeneic hematopoietic stem cell transplantation: Report of two cases and literature review

H. Kasahara; Takehiko Mori; J. Kato; Y. Koda; Sumiko Kohashi; T. Kikuchi; M. Sakurai; Y. Yamane; Shuji Mikami; Kaori Kameyama; Y. Takahashi; Shinichiro Okamoto

doi:10.1111/tid.12461

Post-transplant lymphoproliferative disorder of the adrenal gland after allogeneic hematopoietic stem cell transplantation: Report of two cases and literature review

H. Kasahara, Takehiko Mori, J. Kato, Y. Koda, Sumiko Kohashi, T. Kikuchi, M. Sakurai, Y. Yamane, Shuji Mikami, Kaori Kameyama, Y. Takahashi, Shinichiro Okamoto

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2 Citations (Scopus)

Abstract

Post-transplant lymphoproliferative disorder (PTLD) is one of the life-threatening complications after hematopoietic stem cell transplantation (HSCT) and solid organ transplantation (SOT), and it is associated almost exclusively with Epstein-Barr virus (EBV). We herein report 2 cases of EBV-associated PTLD after allogeneic HSCT localized in the adrenal gland. Both patients developed adrenal tumor within 3 months after HSCT and were successfully treated with rituximab or tapering immunosuppressive agents. Both remained alive without recurrence. A literature review revealed 12 reported cases of PTLD involving the adrenal gland, but the adrenal gland was involved as one of the lesions of advanced-stage PTLD after SOT. To the best of our knowledge, this is the first report to show cases of isolated EBV-associated adrenal PTLD after HSCT. PTLD should be recognized as one of the causes of isolated adrenal tumor after HSCT.

Original language	English
Pages (from-to)	909-914
Number of pages	6
Journal	Transplant Infectious Disease
Volume	17
Issue number	6
DOIs	https://doi.org/10.1111/tid.12461
Publication status	Published - 2015 Dec 1

Keywords

Adrenal gland
Allogeneic hematopoietic stem cell transplantation
Epstein-Barr virus
Post-transplant lymphoproliferative disorder
Rituximab

ASJC Scopus subject areas

Infectious Diseases
Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.12461

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Kasahara, H., Mori, T., Kato, J., Koda, Y., Kohashi, S., Kikuchi, T., Sakurai, M., Yamane, Y., Mikami, S., Kameyama, K., Takahashi, Y., & Okamoto, S. (2015). Post-transplant lymphoproliferative disorder of the adrenal gland after allogeneic hematopoietic stem cell transplantation: Report of two cases and literature review. Transplant Infectious Disease, 17(6), 909-914. https://doi.org/10.1111/tid.12461

Kasahara, H, Mori, T, Kato, J , Koda, Y, Kohashi, S, Kikuchi, T, Sakurai, M, Yamane, Y, Mikami, S, Kameyama, K, Takahashi, Y & Okamoto, S 2015, 'Post-transplant lymphoproliferative disorder of the adrenal gland after allogeneic hematopoietic stem cell transplantation: Report of two cases and literature review', Transplant Infectious Disease, vol. 17, no. 6, pp. 909-914. https://doi.org/10.1111/tid.12461

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abstract = "Post-transplant lymphoproliferative disorder (PTLD) is one of the life-threatening complications after hematopoietic stem cell transplantation (HSCT) and solid organ transplantation (SOT), and it is associated almost exclusively with Epstein-Barr virus (EBV). We herein report 2 cases of EBV-associated PTLD after allogeneic HSCT localized in the adrenal gland. Both patients developed adrenal tumor within 3 months after HSCT and were successfully treated with rituximab or tapering immunosuppressive agents. Both remained alive without recurrence. A literature review revealed 12 reported cases of PTLD involving the adrenal gland, but the adrenal gland was involved as one of the lesions of advanced-stage PTLD after SOT. To the best of our knowledge, this is the first report to show cases of isolated EBV-associated adrenal PTLD after HSCT. PTLD should be recognized as one of the causes of isolated adrenal tumor after HSCT.",

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AU - Koda, Y.

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AU - Kikuchi, T.

AU - Sakurai, M.

AU - Yamane, Y.

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AU - Kameyama, Kaori

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AU - Okamoto, Shinichiro

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AB - Post-transplant lymphoproliferative disorder (PTLD) is one of the life-threatening complications after hematopoietic stem cell transplantation (HSCT) and solid organ transplantation (SOT), and it is associated almost exclusively with Epstein-Barr virus (EBV). We herein report 2 cases of EBV-associated PTLD after allogeneic HSCT localized in the adrenal gland. Both patients developed adrenal tumor within 3 months after HSCT and were successfully treated with rituximab or tapering immunosuppressive agents. Both remained alive without recurrence. A literature review revealed 12 reported cases of PTLD involving the adrenal gland, but the adrenal gland was involved as one of the lesions of advanced-stage PTLD after SOT. To the best of our knowledge, this is the first report to show cases of isolated EBV-associated adrenal PTLD after HSCT. PTLD should be recognized as one of the causes of isolated adrenal tumor after HSCT.

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Post-transplant lymphoproliferative disorder of the adrenal gland after allogeneic hematopoietic stem cell transplantation: Report of two cases and literature review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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