Posterior reversible encephalopathy syndrome concurrent with human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation

Yusuke Ito; Kazuhiro Toyama; Akira Honda; Kumi Nakazaki; Shunya Arai; Mineo Kurokawa

doi:10.1016/j.jiac.2019.07.016

Posterior reversible encephalopathy syndrome concurrent with human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation

Yusuke Ito, Kazuhiro Toyama, Akira Honda, Kumi Nakazaki, Shunya Arai, Mineo Kurokawa

Research output: Contribution to journal › Article › peer-review

Abstract

Posterior reversible encephalopathy syndrome (PRES) and human herpesvirus (HHV)-6 encephalitis are both serious neurological complications post hematopoietic stem cell transplantation. Although infection is one of the important causes of PRES, only few cases have reported the relation between PRES and viral infection. Herein, we report the first adult case of PRES concurrent with HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. This case suggests that HHV-6 reactivation is associated with the pathogenesis of PRES. Also, PRES and HHV-6 encephalitis cause similar symptoms, and switching the immunosuppressant from calcineurin inhibitor to prednisolone for treating PRES may worsen HHV-6 encephalitis. Therefore, we should pay attention to the complication of HHV-6 encephalitis even after PRES is diagnosed.

Original language	English
Pages (from-to)	265-268
Number of pages	4
Journal	Journal of Infection and Chemotherapy
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.jiac.2019.07.016
Publication status	Published - 2020 Feb
Externally published	Yes

Keywords

Allogeneic hematopoietic stem cell transplantation
Human herpesvirus-6 (HHV-6) encephalitis
Posterior reversible encephalopathy syndrome (PRES)

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2019.07.016

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title = "Posterior reversible encephalopathy syndrome concurrent with human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation",

abstract = "Posterior reversible encephalopathy syndrome (PRES) and human herpesvirus (HHV)-6 encephalitis are both serious neurological complications post hematopoietic stem cell transplantation. Although infection is one of the important causes of PRES, only few cases have reported the relation between PRES and viral infection. Herein, we report the first adult case of PRES concurrent with HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. This case suggests that HHV-6 reactivation is associated with the pathogenesis of PRES. Also, PRES and HHV-6 encephalitis cause similar symptoms, and switching the immunosuppressant from calcineurin inhibitor to prednisolone for treating PRES may worsen HHV-6 encephalitis. Therefore, we should pay attention to the complication of HHV-6 encephalitis even after PRES is diagnosed.",

keywords = "Allogeneic hematopoietic stem cell transplantation, Human herpesvirus-6 (HHV-6) encephalitis, Posterior reversible encephalopathy syndrome (PRES)",

author = "Yusuke Ito and Kazuhiro Toyama and Akira Honda and Kumi Nakazaki and Shunya Arai and Mineo Kurokawa",

note = "Publisher Copyright: {\textcopyright} 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases",

year = "2020",

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doi = "10.1016/j.jiac.2019.07.016",

language = "English",

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T1 - Posterior reversible encephalopathy syndrome concurrent with human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation

AU - Ito, Yusuke

AU - Toyama, Kazuhiro

AU - Honda, Akira

AU - Nakazaki, Kumi

AU - Arai, Shunya

AU - Kurokawa, Mineo

PY - 2020/2

Y1 - 2020/2

N2 - Posterior reversible encephalopathy syndrome (PRES) and human herpesvirus (HHV)-6 encephalitis are both serious neurological complications post hematopoietic stem cell transplantation. Although infection is one of the important causes of PRES, only few cases have reported the relation between PRES and viral infection. Herein, we report the first adult case of PRES concurrent with HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. This case suggests that HHV-6 reactivation is associated with the pathogenesis of PRES. Also, PRES and HHV-6 encephalitis cause similar symptoms, and switching the immunosuppressant from calcineurin inhibitor to prednisolone for treating PRES may worsen HHV-6 encephalitis. Therefore, we should pay attention to the complication of HHV-6 encephalitis even after PRES is diagnosed.

AB - Posterior reversible encephalopathy syndrome (PRES) and human herpesvirus (HHV)-6 encephalitis are both serious neurological complications post hematopoietic stem cell transplantation. Although infection is one of the important causes of PRES, only few cases have reported the relation between PRES and viral infection. Herein, we report the first adult case of PRES concurrent with HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. This case suggests that HHV-6 reactivation is associated with the pathogenesis of PRES. Also, PRES and HHV-6 encephalitis cause similar symptoms, and switching the immunosuppressant from calcineurin inhibitor to prednisolone for treating PRES may worsen HHV-6 encephalitis. Therefore, we should pay attention to the complication of HHV-6 encephalitis even after PRES is diagnosed.

KW - Allogeneic hematopoietic stem cell transplantation

KW - Human herpesvirus-6 (HHV-6) encephalitis

KW - Posterior reversible encephalopathy syndrome (PRES)

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ER -

Posterior reversible encephalopathy syndrome concurrent with human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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