Postmortem Diagnosis of Acute Megakaryocytic Leukemia Usefulness of lmmunohistochemistry and Tissue Hemogram

Akihiro Umezawa, Taketo Yamada, Yuuto Ogawa, Shigeru Kuramochi, Yonosuke Watanabe

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2 Citations (Scopus)

Abstract

An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)‐ positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa‐positive blasts and megakaryoblasts were deposited massively in lymph nodes. lmmunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultra‐structural platelet peroxidase in autopsy materials is difficult.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalPathology international
Volume40
Issue number9
DOIs
Publication statusPublished - 1990 Sep

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Keywords

  • Acute megakaryocytic leukemia
  • Glycoprotein IIb/IIIa
  • Immunohistochemistry
  • Tissue hemogram

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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