Postoperative pelvic radiotherapy for cervical cancer patients with positive parametrial invasion

Takashi Uno, Hisao Ito, Koichi Isobe, Yuko Kaneyasu, Naotake Tanaka, Akira Mitsuhashi, Kiyomi Suzuka, Koji Yamazawa, Naoyuki Shigematsu, Jun Itami

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To evaluate patterns of failure in cervical cancer patients with histopathologic parametrial invasion treated with postoperative pelvic radiation therapy. Records of 117 stages IB-IIB cervical cancer patients with parametrial invasion treated with postoperative radiation therapy from 1985 to 2002 were retrospectively reviewed. Patients were divided into two groups based on status of pelvic lymph nodes. Patterns of recurrence and prognosis by status of pelvic lymph nods were statistically analyzed. Status of pelvic lymph nodes had significant impact on both recurrence and survival. Extrapelvic recurrence was observed in 23 of 66 node-positive patients compared with 6 of 51 node-negative patients (P = 0.005). Of 66 patients with a positive pelvic lymph node, 18 developed visceral metastases, whereas only three visceral metastases were noted in the 51 node-negative patients (P = 0.003). Five-year overall survival in node-positive and -negative patients was 52% and 89%, respectively (P = 0.0005). Corresponding rates for recurrence-free survival were 44% and 83%, respectively (P = 0.0002). The correlation between nodal metastasis and prognosis was enhanced when node-positive patients were stratified into two groups based on number of positive nodes (n = 1 and n ≥ 2). Five-year recurrence-free survival rates for patients with negative, one positive, and two or more positive nodes were 83%, 61%, and 31%, respectively (P = 0.0001). Extrapelvic recurrence was uncommon in node-negative patients with parametrial invasion. These findings do not support use of systemic therapy for cervical cancer patients with parametrial invasion if pelvic lymph node metastasis is negative.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalGynecologic Oncology
Volume96
Issue number2
DOIs
Publication statusPublished - 2005 Feb

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Uterine Cervical Neoplasms
Radiotherapy
Recurrence
Lymph Nodes
Neoplasm Metastasis
Survival
Lymph
Survival Rate

Keywords

  • Cervical cancer
  • Lymph node
  • Parametrial invasion
  • Postoperative radiation therapy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Uno, T., Ito, H., Isobe, K., Kaneyasu, Y., Tanaka, N., Mitsuhashi, A., ... Itami, J. (2005). Postoperative pelvic radiotherapy for cervical cancer patients with positive parametrial invasion. Gynecologic Oncology, 96(2), 335-340. https://doi.org/10.1016/j.ygyno.2004.09.061

Postoperative pelvic radiotherapy for cervical cancer patients with positive parametrial invasion. / Uno, Takashi; Ito, Hisao; Isobe, Koichi; Kaneyasu, Yuko; Tanaka, Naotake; Mitsuhashi, Akira; Suzuka, Kiyomi; Yamazawa, Koji; Shigematsu, Naoyuki; Itami, Jun.

In: Gynecologic Oncology, Vol. 96, No. 2, 02.2005, p. 335-340.

Research output: Contribution to journalArticle

Uno, T, Ito, H, Isobe, K, Kaneyasu, Y, Tanaka, N, Mitsuhashi, A, Suzuka, K, Yamazawa, K, Shigematsu, N & Itami, J 2005, 'Postoperative pelvic radiotherapy for cervical cancer patients with positive parametrial invasion', Gynecologic Oncology, vol. 96, no. 2, pp. 335-340. https://doi.org/10.1016/j.ygyno.2004.09.061
Uno, Takashi ; Ito, Hisao ; Isobe, Koichi ; Kaneyasu, Yuko ; Tanaka, Naotake ; Mitsuhashi, Akira ; Suzuka, Kiyomi ; Yamazawa, Koji ; Shigematsu, Naoyuki ; Itami, Jun. / Postoperative pelvic radiotherapy for cervical cancer patients with positive parametrial invasion. In: Gynecologic Oncology. 2005 ; Vol. 96, No. 2. pp. 335-340.
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