Posttranslational regulation of cell-surface colony-stimulating factor-1

Keisuke Horiuchi, Yoshiaki Toyama

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Colony-stimulating factor-1 (CSF-1) plays a central role in the survival, proliferation, differentiation, and function of monocytes and macrophages. CSF-1 is synthesized as both a soluble and a membrane-spanning growth factor. The membrane-spanning isoform is biologically active, but it can also be proteolytically cleaved to generate a soluble growth factor. A recent study revealed that the TNF-α-converting enzyme is involved in this activity, and, moreover, that membrane-spanning CSF-1 undergoes internalization. These findings may have important implications for the posttranslational regulation and the functions of cell-surface CSF-1.

Original languageEnglish
Pages (from-to)215-227
Number of pages13
JournalCritical Reviews in Immunology
Volume28
Issue number3
Publication statusPublished - 2008 Sep 1

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Keywords

  • Colony-stimulating factor-1 (CSF-1)
  • Ectodomain shedding
  • Endocytosis
  • TNF-α-converting enzyme (TACE)/a disintegrin and metalloprotease 17 (ADAM17)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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