Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis

Purusotam Basnet; Katsumichi Matsushige; Koji Hase; Shigetoshi Kadota; Tsuneo Namba

doi:10.1248/bpb.19.655

Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis

Purusotam Basnet, Katsumichi Matsushige, Koji Hase, Shigetoshi Kadota, Tsuneo Namba

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4- di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glycyrrhizin.

Original language	English
Pages (from-to)	655-657
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	19
Issue number	4
DOIs	https://doi.org/10.1248/bpb.19.655
Publication status	Published - 1996 Apr
Externally published	Yes

Keywords

3,4-di-O-caffeoyl quinic acid
hepatoprotective activity
liver
methyl 3,4-di-O-caffeoyl quinate
propolis

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.19.655

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title = "Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis",

abstract = "Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4- di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glycyrrhizin.",

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AU - Basnet, Purusotam

AU - Matsushige, Katsumichi

AU - Hase, Koji

AU - Kadota, Shigetoshi

AU - Namba, Tsuneo

PY - 1996/4

Y1 - 1996/4

N2 - Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4- di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glycyrrhizin.

AB - Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4- di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glycyrrhizin.

KW - 3,4-di-O-caffeoyl quinic acid

KW - hepatoprotective activity

KW - liver

KW - methyl 3,4-di-O-caffeoyl quinate

KW - propolis

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JO - Biological and Pharmaceutical Bulletin

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ER -

Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis

Abstract

Keywords

ASJC Scopus subject areas

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