Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis

Purusotam Basnet, Katsumichi Matsushige, Koji Hase, Shigetoshi Kadota, Tsuneo Namba

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Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4- di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glycyrrhizin.

Original languageEnglish
Pages (from-to)655-657
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Issue number4
Publication statusPublished - 1996 Apr
Externally publishedYes



  • 3,4-di-O-caffeoyl quinic acid
  • hepatoprotective activity
  • liver
  • methyl 3,4-di-O-caffeoyl quinate
  • propolis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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