Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale

K. Iida, Kouji Hase, K. Shimomura, S. Sudo, S. Kadota, T. Namba

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4',5-trihydroxystilbene-4'-O-β-D-(2''-O-galloyl)glucopyranoside (1) and 3,4',5-trihydroxystilbene-4'-O-β-D-(6-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis.

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalPlanta Medica
Volume61
Issue number5
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Rheum officinale
Rheum
Monophenol Monooxygenase
Biosynthesis
Melanins
melanin
biosynthesis
extracts
Chemical Fractionation
chemical analysis
rhizomes
acetone
fractionation
Rhizome
Fractionation
Acetone
Complex Mixtures
drugs
Chemical analysis
Pharmaceutical Preparations

Keywords

  • B-16 melanoma cells
  • hyperpigmentation
  • melanin biosynthesis inhibitor
  • Polygonaceae
  • Rheum officinale Baillon
  • stilbenes
  • tyrosinase inhibitor

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale. / Iida, K.; Hase, Kouji; Shimomura, K.; Sudo, S.; Kadota, S.; Namba, T.

In: Planta Medica, Vol. 61, No. 5, 1995, p. 425-428.

Research output: Contribution to journalArticle

Iida, K. ; Hase, Kouji ; Shimomura, K. ; Sudo, S. ; Kadota, S. ; Namba, T. / Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale. In: Planta Medica. 1995 ; Vol. 61, No. 5. pp. 425-428.
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