Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale

K. Iida; K. Hase; K. Shimomura; S. Sudo; S. Kadota; T. Namba

doi:10.1055/s-2006-958129

Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale

K. Iida, K. Hase, K. Shimomura, S. Sudo, S. Kadota, T. Namba

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4',5-trihydroxystilbene-4'-O-β-D-(2''-O-galloyl)glucopyranoside (1) and 3,4',5-trihydroxystilbene-4'-O-β-D-(6_-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis.

Original language	English
Pages (from-to)	425-428
Number of pages	4
Journal	Planta Medica
Volume	61
Issue number	5
DOIs	https://doi.org/10.1055/s-2006-958129
Publication status	Published - 1995
Externally published	Yes

Keywords

B-16 melanoma cells
Polygonaceae
Rheum officinale Baillon
hyperpigmentation
melanin biosynthesis inhibitor
stilbenes
tyrosinase inhibitor

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1055/s-2006-958129

Cite this

@article{8eb3150b0007416ba124572774506dd8,

title = "Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale",

abstract = "Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4',5-trihydroxystilbene-4'-O-β-D-(2''-O-galloyl)glucopyranoside (1) and 3,4',5-trihydroxystilbene-4'-O-β-D-(6-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis.",

keywords = "B-16 melanoma cells, Polygonaceae, Rheum officinale Baillon, hyperpigmentation, melanin biosynthesis inhibitor, stilbenes, tyrosinase inhibitor",

author = "K. Iida and K. Hase and K. Shimomura and S. Sudo and S. Kadota and T. Namba",

year = "1995",

doi = "10.1055/s-2006-958129",

language = "English",

volume = "61",

pages = "425--428",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "5",

}

TY - JOUR

T1 - Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale

AU - Iida, K.

AU - Hase, K.

AU - Shimomura, K.

AU - Sudo, S.

AU - Kadota, S.

AU - Namba, T.

PY - 1995

Y1 - 1995

N2 - Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4',5-trihydroxystilbene-4'-O-β-D-(2''-O-galloyl)glucopyranoside (1) and 3,4',5-trihydroxystilbene-4'-O-β-D-(6-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis.

AB - Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4',5-trihydroxystilbene-4'-O-β-D-(2''-O-galloyl)glucopyranoside (1) and 3,4',5-trihydroxystilbene-4'-O-β-D-(6-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis.

KW - B-16 melanoma cells

KW - Polygonaceae

KW - Rheum officinale Baillon

KW - hyperpigmentation

KW - melanin biosynthesis inhibitor

KW - stilbenes

KW - tyrosinase inhibitor

UR - http://www.scopus.com/inward/record.url?scp=0028883543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028883543&partnerID=8YFLogxK

U2 - 10.1055/s-2006-958129

DO - 10.1055/s-2006-958129

M3 - Article

C2 - 7480203

AN - SCOPUS:0028883543

SN - 0032-0943

VL - 61

SP - 425

EP - 428

JO - Planta Medica

JF - Planta Medica

IS - 5

ER -

Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this