Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale

K. Iida, K. Hase, K. Shimomura, S. Sudo, S. Kadota, T. Namba

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57 Citations (Scopus)


Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4',5-trihydroxystilbene-4'-O-β-D-(2''-O-galloyl)glucopyranoside (1) and 3,4',5-trihydroxystilbene-4'-O-β-D-(6-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis.

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalPlanta Medica
Issue number5
Publication statusPublished - 1995
Externally publishedYes


  • B-16 melanoma cells
  • Polygonaceae
  • Rheum officinale Baillon
  • hyperpigmentation
  • melanin biosynthesis inhibitor
  • stilbenes
  • tyrosinase inhibitor

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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