TY - JOUR
T1 - Potential and unsolved problems concerning caloric restriction in nutritional therapeutics for the purpose of promoting health and controlling ageing
AU - Shinmura, Ken
PY - 2006/1
Y1 - 2006/1
N2 - Overeating and obesity are major health problems even in the elderly since they lead to the metabolic syndrome, resulting in an increase in cardiovascular disease. The development of novel nutritional therapeutics for the purpose of promoting health and controlling ageing process aims at the self-helping elderly. Caloric restriction (CR) has been widely investigated as a powerful method that can prevent and reverse senescent changes. CR might counteract the deleterious aspects of metabolic syndrome and may prolong lifespan even in humans. However, we should keep in mind that several fundamental issues about CR still remain unsolved. In addition, malnutrition and nutritional troubles are emerging problems in the elderly in care. Thus, we emphasize that nutritional intervention aiming at ageing control should be established and be developed as a custom-made therapeutics for the elderly, who show great individual variation.
AB - Overeating and obesity are major health problems even in the elderly since they lead to the metabolic syndrome, resulting in an increase in cardiovascular disease. The development of novel nutritional therapeutics for the purpose of promoting health and controlling ageing process aims at the self-helping elderly. Caloric restriction (CR) has been widely investigated as a powerful method that can prevent and reverse senescent changes. CR might counteract the deleterious aspects of metabolic syndrome and may prolong lifespan even in humans. However, we should keep in mind that several fundamental issues about CR still remain unsolved. In addition, malnutrition and nutritional troubles are emerging problems in the elderly in care. Thus, we emphasize that nutritional intervention aiming at ageing control should be established and be developed as a custom-made therapeutics for the elderly, who show great individual variation.
KW - Ageing
KW - Caloric restriction
KW - Lifespan
KW - Nutrition
KW - Senescence
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U2 - 10.3143/geriatrics.43.89
DO - 10.3143/geriatrics.43.89
M3 - Article
C2 - 16521813
AN - SCOPUS:33645092164
VL - 43
SP - 89
EP - 91
JO - Japanese Journal of Geriatrics
JF - Japanese Journal of Geriatrics
SN - 0300-9173
IS - 1
ER -